Tissue-level properties of the tibia
| . | WT . | KO . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Sedentary . | 30′-Exercise . | 60′-Exercise . | Sedentary . | 30′-Exercise . | 60′-Exercise . | Main effects . | |||
| (n = 11) | (n = 9) | (n = 11) | (n = 12) | (n = 11) | (n = 12) | G | A | G×A | |
| TMD (g K2HPO4/cm3) | 1.032 (0.040) | 1.045 (0.07) | 1.037 (0.047) | 1.045 (0.071) | 0.997 (0.062) | 1.021 (0.056) | 0.969 | 0.225 | 0.953 |
| Yield stress (MPa) | 143.4 (14.3) | 134.6 (16.3) | 117.9 (21.0)a | 138.2 (17.2) | 124.6 (8.2) | 126.3 (16.6) | 0.823 | 0.001 | 0.169 |
| Ultimate stress (MPa) | 146.1 (13.3) | 160.6 (31.0) | 139.3 (15.7) | 159.5 (18.2) | 143.1 (20.9) | 157.1 (18.4) | 0.188 | 0.646 | 0.019 |
| Yield strain (μe) | 19,193 (2,796) | 18,349 (2,283) | 19,702 (3,852) | 17,841 (3,077) | 17,278 (1,751) | 18,811 (2,129) | 0.125 | 0.173 | 0.916 |
| Ultimate strain (μe) | 21,933 (6,264) | 28,928 (9,153) | 31,318 (6,121)a | 29,081 (7,422) | 24,996 (7,517) | 31,306 (3,785) | 0.427 | 0.023 | 0.049 |
| Modulus (GPa) | 8.75 (1.14) | 8.73 (1.48) | 6.75 (1.20)a | 8.61 (1.36) | 8.03 (0.60) | 7.43 (0.70) | 0.68 | <0.001 | 0.100 |
| . | WT . | KO . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Sedentary . | 30′-Exercise . | 60′-Exercise . | Sedentary . | 30′-Exercise . | 60′-Exercise . | Main effects . | |||
| (n = 11) | (n = 9) | (n = 11) | (n = 12) | (n = 11) | (n = 12) | G | A | G×A | |
| TMD (g K2HPO4/cm3) | 1.032 (0.040) | 1.045 (0.07) | 1.037 (0.047) | 1.045 (0.071) | 0.997 (0.062) | 1.021 (0.056) | 0.969 | 0.225 | 0.953 |
| Yield stress (MPa) | 143.4 (14.3) | 134.6 (16.3) | 117.9 (21.0)a | 138.2 (17.2) | 124.6 (8.2) | 126.3 (16.6) | 0.823 | 0.001 | 0.169 |
| Ultimate stress (MPa) | 146.1 (13.3) | 160.6 (31.0) | 139.3 (15.7) | 159.5 (18.2) | 143.1 (20.9) | 157.1 (18.4) | 0.188 | 0.646 | 0.019 |
| Yield strain (μe) | 19,193 (2,796) | 18,349 (2,283) | 19,702 (3,852) | 17,841 (3,077) | 17,278 (1,751) | 18,811 (2,129) | 0.125 | 0.173 | 0.916 |
| Ultimate strain (μe) | 21,933 (6,264) | 28,928 (9,153) | 31,318 (6,121)a | 29,081 (7,422) | 24,996 (7,517) | 31,306 (3,785) | 0.427 | 0.023 | 0.049 |
| Modulus (GPa) | 8.75 (1.14) | 8.73 (1.48) | 6.75 (1.20)a | 8.61 (1.36) | 8.03 (0.60) | 7.43 (0.70) | 0.68 | <0.001 | 0.100 |
Two-way ANOVA identified the main effects for genotype (G), activity (A), and their interaction (G × A). Tukey post-hoc analysis identified significant differences between groups. Mean (± SD).
P < 0.05 versus Sedentary control.