Table 3.

List of D. melanogaster lines utilized in this study

Line nameLine IDLine sourceLine description
nrv2::YFP CPTI001455 Kyoto Stock Centre - Drosophila Genomics and Genetic Resources (DGRC) (https://www.dgrc.kit.ac.jp/Nervana 2 gene YFP protein trap line (Lowe et al., 2014) 
Flo-2::YFP CPTI001427 DGRC Flotillin 2 gene YFP protein trap line 
Cip4::YFP CPTI003231 DGRC Cdc42-interacting protein 4 gene YFP protein trap line 
Vha55::YFP CPTI002645 DGRC Vacuolar H+-ATPase 55kD subunit gene YFP protein trap line 
Atpalpha::YFP CPTI002636 DGRC Na pump α subunit gene YFP protein trap line 
Nrg::YFP CPTI002761 DGRC Neuroglian gene YFP protein trap line 
Lac::YFP CPTI001714 DGRC Lachesin gene YFP protein trap line 
alpha-Cat::YFP CPTI002408 DGRC α Catenin gene YFP protein trap line 
Pdi::YFP CPTI002342 DGRC Protein disulfide isomerase gene YFP protein trap line 
gs2::YFP CPTI001918 DGRC Glutamine synthetase 2 gene YFP protein trap line 
Repo-GAL4 RRID:BDSC_7415 Bloomington Drosophila Stock Center (BDSC) (https://bdsc.indiana.edu/index.htmlExpresses GAL4 in glia 
UAS-mCD8-mCherry/cyo-GFP RRID:BDSC_27391 BDSC Expresses Cherry RFP fused to the mouse CD8 extracellular and transmembrane domains for membrane targeting under UAS control 
UAS-mCD8-GFP/cyo-GFP RRID:BDSC 63045 BDSC Expresses GFP fused to the mouse CD8 extracellular and transmembrane domains for membrane targeting under UAS control 
Cyo-GFP/Gla; tm6, tb/pri Crossed from BDSC stocks BDSC A double balanced stock carrying Cyo-GFP over gla on the 2nd chromosome and tm6, tb over prickle on the 3rd chromosome 
Atpalpha-RNAi RRID:BDSC 32913 BDSC Expresses dsRNA for RNAi of atpalpha under UAS control in the VALIUM20 vector 
alpha-Cat-RNAi KK107298 VDRC Expresses dsRNA for RNAi of alpha-Cat under UAS control in the pUAST vector pMF3 
nrv2-RNAi GD960 VDRC Expresses dsRNA for RNAi of nrv2 under UAS control in the pUAST vector pMF3 
shot-RNAi RRID:BDSC 28336 BDSC Expresses dsRNA for RNAi of shot under UAS control in the VALIUM10 vector 
Vha55-RNAi GD 9363 VDRC Expresses dsRNA for RNAi of Vha55 under UAS control in the pUAST vector pMF3 
Lac-RNAi GD 35524 VDRC Expresses dsRNA for RNAi of Lac under UAS control in the pUAST vector pMF3 
Flo-2-RNAi VSH 330316 VDRC Expresses dsRNA for RNAi of Flo-2 under UAS control in the WALIUM20 vector 
gs2-RNAi GD 9378 VDRC Expresses dsRNA for RNAi of gs2 under UAS control in the pUAST vector pMF3 
Pdi-RNAi GD13418 VDRC Expresses dsRNA for RNAi of Pdi under UAS control in the pUAST vector pMF3 
mCherry-RNAi RRID:BDSC 35785 BDSC Expresses dsRNA for RNAi of mCherry under UAS control in the VALIUM20 vector 
nrv2-GAL4 RRID: BDSC 6800 BDSC Expresses GAL4 in wrapping glia 
46F-GALl4 − Gift from Dr. Stefanie Schirmeier Expresses GAL4 in perineurial glia (Xie and Auld, 2011) 
Mdr65-GAL4 RRID: BDSC 50472 BDSC Expresses GAL4 in subperineurial glia 
Line nameLine IDLine sourceLine description
nrv2::YFP CPTI001455 Kyoto Stock Centre - Drosophila Genomics and Genetic Resources (DGRC) (https://www.dgrc.kit.ac.jp/Nervana 2 gene YFP protein trap line (Lowe et al., 2014) 
Flo-2::YFP CPTI001427 DGRC Flotillin 2 gene YFP protein trap line 
Cip4::YFP CPTI003231 DGRC Cdc42-interacting protein 4 gene YFP protein trap line 
Vha55::YFP CPTI002645 DGRC Vacuolar H+-ATPase 55kD subunit gene YFP protein trap line 
Atpalpha::YFP CPTI002636 DGRC Na pump α subunit gene YFP protein trap line 
Nrg::YFP CPTI002761 DGRC Neuroglian gene YFP protein trap line 
Lac::YFP CPTI001714 DGRC Lachesin gene YFP protein trap line 
alpha-Cat::YFP CPTI002408 DGRC α Catenin gene YFP protein trap line 
Pdi::YFP CPTI002342 DGRC Protein disulfide isomerase gene YFP protein trap line 
gs2::YFP CPTI001918 DGRC Glutamine synthetase 2 gene YFP protein trap line 
Repo-GAL4 RRID:BDSC_7415 Bloomington Drosophila Stock Center (BDSC) (https://bdsc.indiana.edu/index.htmlExpresses GAL4 in glia 
UAS-mCD8-mCherry/cyo-GFP RRID:BDSC_27391 BDSC Expresses Cherry RFP fused to the mouse CD8 extracellular and transmembrane domains for membrane targeting under UAS control 
UAS-mCD8-GFP/cyo-GFP RRID:BDSC 63045 BDSC Expresses GFP fused to the mouse CD8 extracellular and transmembrane domains for membrane targeting under UAS control 
Cyo-GFP/Gla; tm6, tb/pri Crossed from BDSC stocks BDSC A double balanced stock carrying Cyo-GFP over gla on the 2nd chromosome and tm6, tb over prickle on the 3rd chromosome 
Atpalpha-RNAi RRID:BDSC 32913 BDSC Expresses dsRNA for RNAi of atpalpha under UAS control in the VALIUM20 vector 
alpha-Cat-RNAi KK107298 VDRC Expresses dsRNA for RNAi of alpha-Cat under UAS control in the pUAST vector pMF3 
nrv2-RNAi GD960 VDRC Expresses dsRNA for RNAi of nrv2 under UAS control in the pUAST vector pMF3 
shot-RNAi RRID:BDSC 28336 BDSC Expresses dsRNA for RNAi of shot under UAS control in the VALIUM10 vector 
Vha55-RNAi GD 9363 VDRC Expresses dsRNA for RNAi of Vha55 under UAS control in the pUAST vector pMF3 
Lac-RNAi GD 35524 VDRC Expresses dsRNA for RNAi of Lac under UAS control in the pUAST vector pMF3 
Flo-2-RNAi VSH 330316 VDRC Expresses dsRNA for RNAi of Flo-2 under UAS control in the WALIUM20 vector 
gs2-RNAi GD 9378 VDRC Expresses dsRNA for RNAi of gs2 under UAS control in the pUAST vector pMF3 
Pdi-RNAi GD13418 VDRC Expresses dsRNA for RNAi of Pdi under UAS control in the pUAST vector pMF3 
mCherry-RNAi RRID:BDSC 35785 BDSC Expresses dsRNA for RNAi of mCherry under UAS control in the VALIUM20 vector 
nrv2-GAL4 RRID: BDSC 6800 BDSC Expresses GAL4 in wrapping glia 
46F-GALl4 − Gift from Dr. Stefanie Schirmeier Expresses GAL4 in perineurial glia (Xie and Auld, 2011) 
Mdr65-GAL4 RRID: BDSC 50472 BDSC Expresses GAL4 in subperineurial glia 

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