Statistical analysis of fiber size measurements
| . | . | Innervated . | Denervated . | % Change . |
|---|---|---|---|---|
| 3-day denervation (Fig. 1 B) | Median | 3706 | 3084 | −20.63 |
| Skewness | 0.27 | 0.43 | −37.2 | |
| Brunner-Manzel test: P value = 1.00E+00 | ||||
| A-statistic = 0.61 | ||||
| 7-day denervation (Fig. 1 B) | Innervated | Denervated | % Change | |
| Median | 3452 | 2842 | −21.46 | |
| Skewness | 1.16 | 0.3 | −287 | |
| Brunner-Manzel test: P value = 1.00E+00 | ||||
| A-statistic = 0.63 | ||||
| 14-day denervation (Fig. 1 B) | Innervated | Denervated | % Change | |
| Median | 2779 | 2058 | −35.03 | |
| Skewness | 1.03 | 0.8 | −23 | |
| Brunner-Manzel test: P value = 1.00E+00 | ||||
| A-statistic = 0.62 | ||||
| 28-day denervation (Fig. 1 B) | Innervated | Denervated | % Change | |
| Median | 3411 | 2358 | −44.65 | |
| Skewness | 0.18 | 0.67 | 73.13 | |
| Brunner-Manzel test: P value = 1.00E+00 | ||||
| A-statistic = 0.68 | ||||
| shGankyrin (Fig. 3 D) | Non-transfected | Transfected | % Change | |
| Median | 1482 | 1772 | 19.56 | |
| Skewness | 0.94 | 1.80 | 91.23 | |
| Brunner-Manzel test: P value = 2.94E−12 | ||||
| A-statistic = 0.28 | ||||
| shPAX4 (Fig. 4 B) | Non-transfected | Transfected | % Change | |
| Median | 1883 | 2155 | 14.4 | |
| Skewness | 0.94 | 0.92 | −2.13 | |
| Brunner-Manzel test: P value = 0.00E+00 | ||||
| A-statistic = 0.38 | ||||
| . | . | Innervated . | Denervated . | % Change . |
|---|---|---|---|---|
| 3-day denervation (Fig. 1 B) | Median | 3706 | 3084 | −20.63 |
| Skewness | 0.27 | 0.43 | −37.2 | |
| Brunner-Manzel test: P value = 1.00E+00 | ||||
| A-statistic = 0.61 | ||||
| 7-day denervation (Fig. 1 B) | Innervated | Denervated | % Change | |
| Median | 3452 | 2842 | −21.46 | |
| Skewness | 1.16 | 0.3 | −287 | |
| Brunner-Manzel test: P value = 1.00E+00 | ||||
| A-statistic = 0.63 | ||||
| 14-day denervation (Fig. 1 B) | Innervated | Denervated | % Change | |
| Median | 2779 | 2058 | −35.03 | |
| Skewness | 1.03 | 0.8 | −23 | |
| Brunner-Manzel test: P value = 1.00E+00 | ||||
| A-statistic = 0.62 | ||||
| 28-day denervation (Fig. 1 B) | Innervated | Denervated | % Change | |
| Median | 3411 | 2358 | −44.65 | |
| Skewness | 0.18 | 0.67 | 73.13 | |
| Brunner-Manzel test: P value = 1.00E+00 | ||||
| A-statistic = 0.68 | ||||
| shGankyrin (Fig. 3 D) | Non-transfected | Transfected | % Change | |
| Median | 1482 | 1772 | 19.56 | |
| Skewness | 0.94 | 1.80 | 91.23 | |
| Brunner-Manzel test: P value = 2.94E−12 | ||||
| A-statistic = 0.28 | ||||
| shPAX4 (Fig. 4 B) | Non-transfected | Transfected | % Change | |
| Median | 1883 | 2155 | 14.4 | |
| Skewness | 0.94 | 0.92 | −2.13 | |
| Brunner-Manzel test: P value = 0.00E+00 | ||||
| A-statistic = 0.38 | ||||
Summary statistics for fiber size analyses that are presented in Fig. 1 B; Fig. 3 D; and Fig. 4 B, based on our recent methodology paper (Gilda et al., 2021). Regarding A-statistic, if 0 ≤ A<0.5 then dataset1 (non-transfected) is stochastically less than dataset2 (transfected). If 0.5 ≤ A<1 then dataset1 (innervated) is stochastically greater than dataset2 (denervated). The A-statistics is a direct measure of the fiber size effect (Gilda et al., 2021), and it shows a beneficial effect on cell size by the specific shRNAs. Such an effect can be simply missed by traditional measurements of median, average, and Student’s t test.