Table 1. Alterations in mitochondrial... | Rockefeller University Press

Table 1.

Alterations in mitochondrial dynamics affect lifespan in model organisms

Genetic manipulation	Effect on mitochondrial dynamics	Model organism	Lifespan	Reference
Transient upregulation of Drp1	Increased fission	D. melanogaster	Increase in lifespan	Rana et al., 2017
Parkin E3 overexpression	Increased fission	D. melanogaster	Increase in lifespan	Rana et al., 2017
Intestine-specific overexpression of drp-1	Increased fission	C. elegans	Increase in lifespan	Han et al., 2017
Mfn2 knockout in skeletal muscle	Impaired fusion, Swollen mitochondria upon aging	Mice	Premature aging, No change in lifespan	Sebastián et al., 2016
Knockdown of drp-1 or overexpression of fzo-1	Increased fusion	C. elegans	No change in lifespan	Weir et al., 2017

Genetic manipulation	Effect on mitochondrial dynamics	Model organism	Lifespan	Reference
Transient upregulation of Drp1	Increased fission	D. melanogaster	Increase in lifespan	Rana et al., 2017
Parkin E3 overexpression	Increased fission	D. melanogaster	Increase in lifespan	Rana et al., 2017
Intestine-specific overexpression of drp-1	Increased fission	C. elegans	Increase in lifespan	Han et al., 2017
Mfn2 knockout in skeletal muscle	Impaired fusion, Swollen mitochondria upon aging	Mice	Premature aging, No change in lifespan	Sebastián et al., 2016
Knockdown of drp-1 or overexpression of fzo-1	Increased fusion	C. elegans	No change in lifespan	Weir et al., 2017