Alterations in mitochondrial dynamics affect lifespan in model organisms
| Genetic manipulation . | Effect on mitochondrial dynamics . | Model organism . | Lifespan . | Reference . |
|---|---|---|---|---|
| Transient upregulation of Drp1 | Increased fission | D. melanogaster | Increase in lifespan | Rana et al., 2017 |
| Parkin E3 overexpression | Increased fission | D. melanogaster | Increase in lifespan | Rana et al., 2017 |
| Intestine-specific overexpression of drp-1 | Increased fission | C. elegans | Increase in lifespan | Han et al., 2017 |
| Mfn2 knockout in skeletal muscle | Impaired fusion, Swollen mitochondria upon aging | Mice | Premature aging, No change in lifespan | Sebastián et al., 2016 |
| Knockdown of drp-1 or overexpression of fzo-1 | Increased fusion | C. elegans | No change in lifespan | Weir et al., 2017 |
| Genetic manipulation . | Effect on mitochondrial dynamics . | Model organism . | Lifespan . | Reference . |
|---|---|---|---|---|
| Transient upregulation of Drp1 | Increased fission | D. melanogaster | Increase in lifespan | Rana et al., 2017 |
| Parkin E3 overexpression | Increased fission | D. melanogaster | Increase in lifespan | Rana et al., 2017 |
| Intestine-specific overexpression of drp-1 | Increased fission | C. elegans | Increase in lifespan | Han et al., 2017 |
| Mfn2 knockout in skeletal muscle | Impaired fusion, Swollen mitochondria upon aging | Mice | Premature aging, No change in lifespan | Sebastián et al., 2016 |
| Knockdown of drp-1 or overexpression of fzo-1 | Increased fusion | C. elegans | No change in lifespan | Weir et al., 2017 |