Essential criteria for components of the hair cell sensory transduction channel complex are satisfied for TMC proteins (+) but not for PIEZO proteins (−)
| Criteria | TMC1 | TMC2 | PIEZO1 | PIEZO2 |
|---|---|---|---|---|
| Gene expression in neonatal hair cells | + | + | − | + |
| Gene expression in adult hair cells | + | − | − | − |
| Protein localization at hair bundle tips | + | + | − | − |
| Loss of sensory transduction in KOs | + | + | − | − |
| Point mutations alter channel properties | + | + | ? | ? |
| Loss of auditory function in mice | + | − | − | − |
| Loss of auditory function in humans | + | − | − | − |
| Criteria | TMC1 | TMC2 | PIEZO1 | PIEZO2 |
|---|---|---|---|---|
| Gene expression in neonatal hair cells | + | + | − | + |
| Gene expression in adult hair cells | + | − | − | − |
| Protein localization at hair bundle tips | + | + | − | − |
| Loss of sensory transduction in KOs | + | + | − | − |
| Point mutations alter channel properties | + | + | ? | ? |
| Loss of auditory function in mice | + | − | − | − |
| Loss of auditory function in humans | + | − | − | − |