Table 2. Activation kinetics parameters... | Rockefeller University Press

Table 2.

Activation kinetics parameters

	τ_Activation (ms)
	−140 mV	n	−120 mV	n	−100 mV	n
Holo HCN4	580 ± 42	44	1,360 ± 140	45	2,870 ± 330	30
+ Vehicle	682 ± 99	6	1,270 ± 160	5	2,550 ± 550	4
+1 µM CBD	436 ± 68	6	790 ± 100	7	1,560 ± 340	5
+5 µM CBD	256 ± 36	7	405 ± 59	8	951 ± 130	9
+10 µM CBD	271 ± 32	11	430. ± 33	11	901 ± 68	10
+20 µM CBD	357 ± 50	11	560. ± 43	11	1,020 ± 120	11
+10 µM diC8-PIP₂; +5 µM CBD	319 ± 35	4	601 ± 64	5	955 ± 77	4
	−150 mV	n	−130 mV	n	−110 mV	n
Apo HCN4	430 ± 110	5	970 ± 120	7	1,471 ± 96	4
+5 µM CBD	276 ± 25	7	445 ± 37	7	1,075 ± 91	7

	τ_Activation (ms)
	−140 mV	n	−120 mV	n	−100 mV	n
Holo HCN4	580 ± 42	44	1,360 ± 140	45	2,870 ± 330	30
+ Vehicle	682 ± 99	6	1,270 ± 160	5	2,550 ± 550	4
+1 µM CBD	436 ± 68	6	790 ± 100	7	1,560 ± 340	5
+5 µM CBD	256 ± 36	7	405 ± 59	8	951 ± 130	9
+10 µM CBD	271 ± 32	11	430. ± 33	11	901 ± 68	10
+20 µM CBD	357 ± 50	11	560. ± 43	11	1,020 ± 120	11
+10 µM diC8-PIP₂; +5 µM CBD	319 ± 35	4	601 ± 64	5	955 ± 77	4
	−150 mV	n	−130 mV	n	−110 mV	n
Apo HCN4	430 ± 110	5	970 ± 120	7	1,471 ± 96	4
+5 µM CBD	276 ± 25	7	445 ± 37	7	1,075 ± 91	7

Average ± S.E.M. for activation τ for the three most hyperpolarized voltages measured.