Amino acid sequences of the selectivity filters of different NaV and CaV channels
| Channel | Locus EEEE | Locus DCS |
|---|---|---|
| HsCaV1.1 | EEEE | DSQE |
| HsCaV1.2 | EEEE | DSED |
| HsCaV2.1 | EEEE | DEQN |
| HsCaV2.2 | EEEE | DAME |
| HsCaV2.3 | EEEE | TEQE |
| HsCaV3.1 | EEDD | DVNG |
| Am-CaV4 | DEEA | DEED |
| DSC1 | DEEA | NEED |
| BSC1 | DEEA | NEED |
| Am-NaV | DEKA | NEQG |
| Channel | Locus EEEE | Locus DCS |
|---|---|---|
| HsCaV1.1 | EEEE | DSQE |
| HsCaV1.2 | EEEE | DSED |
| HsCaV2.1 | EEEE | DEQN |
| HsCaV2.2 | EEEE | DAME |
| HsCaV2.3 | EEEE | TEQE |
| HsCaV3.1 | EEDD | DVNG |
| Am-CaV4 | DEEA | DEED |
| DSC1 | DEEA | NEED |
| BSC1 | DEEA | NEED |
| Am-NaV | DEKA | NEQG |
The EEEE locus is the locus responsible for divalent/monovalent selectivity, while the DCS (divalent cation selectivity) is the locus responsible for the selectivity between divalent cations (Ba2+, Ca2+, Sr2+) (Cens et al., 2007). For CaV4, Am-NaV, DSC1, and BSC1 the location of the DCS locus is taken relative to the conserved tryptophan in each pore domain.
Sharing content requires targeting cookies to be enabled. Please update your cookie preferences to use this feature.