Plethysmography—long-term tirasemtiv treatment
| . | Week 0c . | Week 4d . | # of mice . | Age of mice in months . | ||
|---|---|---|---|---|---|---|
| Acta1(Wt)—vehicle | 7 | 9 | ||||
| Respiratory rate (per minute) | 315 ± 50 | 330 ± 17 | 255 ± 53 | 310 ± 24 | ||
| Tidal volume (ml/kg) | 9.5 ± 2.2 | 14.6 ± 4 | 8.6 ± 1.2 | 13 ± 2.3 | ||
| Minute volume (ml/kg/minute) | 3,027 ± 844 | 4,863 ± 1511 | 2,164 ± 480 | 4,040 ± 565 | ||
| Acta1(Wt)—tirasemtiva | 8 | 9 | ||||
| Respiratory rate (per minute) | 322 ± 44 | 331 ± 13 | 284 ± 50 | 310 ± 23 | ||
| Tidal volume (ml/kg) | 8.9 ± 2 | 14.5 ± 3.2 | 7.9 ± 1.5 | 12.4 ± 1.7 | ||
| Minute volume (ml/kg/minute) | 2,905 ± 698 | 4,782 ± 1,080 | 2,210 ± 450 | 3,848 ± 576 | ||
| Acta1(D286G)—vehicleb | 13 | 9 | ||||
| Respiratory rate (per minute) | 357 ± 37 | 330 ± 23 | 319 ± 29 | 315 ± 25 | ||
| Tidal volume (ml/kg) | 9.5 ± 2.1 | 14 ± 2.3 | 8.7 ± 1.7 | 14 ± 2.1 | ||
| Minute volume (ml/kg/minute) | 3,396 ± 1,081 | 4,613 ± 812 | 2,724 ± 554 | 4,391 ± 768 | ||
| Acta1(D286G)—tirasemtiv | 15 | 9 | ||||
| Respiratory rate (per minute) | 331 ± 47 | 324 ± 19 | 270 ± 47 | 277a ± 37 | ||
| Tidal volume (ml/kg) | 8.9 ± 1.4 | 14.5 ± 3 | 9.2 ± 2 | 14.3 ± 2.4 | ||
| Minute volume (ml/kg/minute) | 2,924 ± 641 | 4,711 ± 1,012 | 2,392 ± 448 | 3,933 ± 827 | ||
| . | Week 0c . | Week 4d . | # of mice . | Age of mice in months . | ||
|---|---|---|---|---|---|---|
| Acta1(Wt)—vehicle | 7 | 9 | ||||
| Respiratory rate (per minute) | 315 ± 50 | 330 ± 17 | 255 ± 53 | 310 ± 24 | ||
| Tidal volume (ml/kg) | 9.5 ± 2.2 | 14.6 ± 4 | 8.6 ± 1.2 | 13 ± 2.3 | ||
| Minute volume (ml/kg/minute) | 3,027 ± 844 | 4,863 ± 1511 | 2,164 ± 480 | 4,040 ± 565 | ||
| Acta1(Wt)—tirasemtiva | 8 | 9 | ||||
| Respiratory rate (per minute) | 322 ± 44 | 331 ± 13 | 284 ± 50 | 310 ± 23 | ||
| Tidal volume (ml/kg) | 8.9 ± 2 | 14.5 ± 3.2 | 7.9 ± 1.5 | 12.4 ± 1.7 | ||
| Minute volume (ml/kg/minute) | 2,905 ± 698 | 4,782 ± 1,080 | 2,210 ± 450 | 3,848 ± 576 | ||
| Acta1(D286G)—vehicleb | 13 | 9 | ||||
| Respiratory rate (per minute) | 357 ± 37 | 330 ± 23 | 319 ± 29 | 315 ± 25 | ||
| Tidal volume (ml/kg) | 9.5 ± 2.1 | 14 ± 2.3 | 8.7 ± 1.7 | 14 ± 2.1 | ||
| Minute volume (ml/kg/minute) | 3,396 ± 1,081 | 4,613 ± 812 | 2,724 ± 554 | 4,391 ± 768 | ||
| Acta1(D286G)—tirasemtiv | 15 | 9 | ||||
| Respiratory rate (per minute) | 331 ± 47 | 324 ± 19 | 270 ± 47 | 277a ± 37 | ||
| Tidal volume (ml/kg) | 8.9 ± 1.4 | 14.5 ± 3 | 9.2 ± 2 | 14.3 ± 2.4 | ||
| Minute volume (ml/kg/minute) | 2,924 ± 641 | 4,711 ± 1,012 | 2,392 ± 448 | 3,933 ± 827 | ||