Plethysmography—acute tirasemtiv treatment
| . | Vehicle . | Tirasemtiv . | . | . | ||
|---|---|---|---|---|---|---|
| Rest | 5% CO2 | Rest | 5% CO2 | # of mice | Age of mice in months | |
| Acta1(wt)a | 14 | 8 | ||||
| Respiratory rate (per minute) | 191 ± 23 | 182 ± 37 | 194 ± 18 | 179 ± 23 | ||
| Tidal volume (ml/kg) | 10.4 ± 1 | 10.3 ± 1 | 10.6 ± 1.1 | 10.1 ± 0.8 | ||
| Minute volume (ml/kg/minute) | 1,997 ± 318 | 1,876 ± 317 | 2,057 ± 338 | 1,690 ± 568 | ||
| Acta1(D286G)b | 14 | 8 | ||||
| Respiratory rate (per minute) | 184 ± 25 | 168 ± 22 | 175 ± 21 | 164 ± 31 | ||
| Tidal volume (ml/kg) | 10.1 ± 1.1 | 9.4 ± 1.2 | 9.9 ± 0.9 | 9.6 ± 1.2 | ||
| Minute volume (ml/kg/minute) | 1,859 ± 338 | 1,485 ± 519 | 1,766 ± 307 | 1,504 ± 598 | ||
| . | Vehicle . | Tirasemtiv . | . | . | ||
|---|---|---|---|---|---|---|
| Rest | 5% CO2 | Rest | 5% CO2 | # of mice | Age of mice in months | |
| Acta1(wt)a | 14 | 8 | ||||
| Respiratory rate (per minute) | 191 ± 23 | 182 ± 37 | 194 ± 18 | 179 ± 23 | ||
| Tidal volume (ml/kg) | 10.4 ± 1 | 10.3 ± 1 | 10.6 ± 1.1 | 10.1 ± 0.8 | ||
| Minute volume (ml/kg/minute) | 1,997 ± 318 | 1,876 ± 317 | 2,057 ± 338 | 1,690 ± 568 | ||
| Acta1(D286G)b | 14 | 8 | ||||
| Respiratory rate (per minute) | 184 ± 25 | 168 ± 22 | 175 ± 21 | 164 ± 31 | ||
| Tidal volume (ml/kg) | 10.1 ± 1.1 | 9.4 ± 1.2 | 9.9 ± 0.9 | 9.6 ± 1.2 | ||
| Minute volume (ml/kg/minute) | 1,859 ± 338 | 1,485 ± 519 | 1,766 ± 307 | 1,504 ± 598 | ||