In vivo plantar flexor muscle mechanics—long-term tirasemtiv treatment
Frequency (Hz) . | 20 . | 100 . | # of mice . | Age of mice in months . | |
|---|---|---|---|---|---|
| Acta1(D286G)—vehicle | 13 | 9 | |||
| Absolute force (mN) | 69 ± 17 | 334 ± 31 | |||
| Normalized force (mN/mg) | 0.6 ± 0.1 | 3.0 ± 0.2 | |||
| Relative force (% of maximum) | 21 ± 4.6 | 100 ± 6.1 | |||
| Acta1(D286G)—Tirasemtiv | 12 | 9 | |||
| Absolute force (mN) | 83 ± 31 | 293a ± 32 | |||
| Normalized force (mN/mg) | 0.8a ± 0.3 | 2.9 ± 0.4 | |||
| Relative force (% of maximum) | 29 ± 9.3a | 100 ± 13 | |||
Frequency (Hz) . | 20 . | 100 . | # of mice . | Age of mice in months . | |
|---|---|---|---|---|---|
| Acta1(D286G)—vehicle | 13 | 9 | |||
| Absolute force (mN) | 69 ± 17 | 334 ± 31 | |||
| Normalized force (mN/mg) | 0.6 ± 0.1 | 3.0 ± 0.2 | |||
| Relative force (% of maximum) | 21 ± 4.6 | 100 ± 6.1 | |||
| Acta1(D286G)—Tirasemtiv | 12 | 9 | |||
| Absolute force (mN) | 83 ± 31 | 293a ± 32 | |||
| Normalized force (mN/mg) | 0.8a ± 0.3 | 2.9 ± 0.4 | |||
| Relative force (% of maximum) | 29 ± 9.3a | 100 ± 13 | |||
Tirasemtiv versus Vehicle (P < 0.5).