Table 1. Summary of enzyme inhibition... | Rockefeller University Press

Table 1.

Summary of enzyme inhibition assays from Fig. 1

Enzyme	IC₅₀ GTP (µM) best-fit	IC₅₀ GTP (µM) 90% confidence interval	Hill best-fit	Hill 90% confidence interval
IMPDH1(595)-WT	1,150	1,040–1,230	2.3	2.2–3.0
IMPDH1(595)-S477D	603	590–631	3.7	3.5–4.5
IMPDH1(595)-Y12A	473	462–492	4.5	4.2–5.5
IMPDH1(595)-Y12A-S477D	464	458–486	4.1	3.9–5.0
IMPDH1(546)-WT	757	725–792	4.6	3.9–5.7
IMPDH1(546)-S477D	486	452–524	3.7	3.0–4.9
IMPDH1(546)-Y12A	538	505–575	4.0	3.3–5.3
IMPDH1(546)-Y12A-S477D	458	450–480	4.2	4.0–5.1

Enzyme	IC₅₀ GTP (µM) best-fit	IC₅₀ GTP (µM) 90% confidence interval	Hill best-fit	Hill 90% confidence interval
IMPDH1(595)-WT	1,150	1,040–1,230	2.3	2.2–3.0
IMPDH1(595)-S477D	603	590–631	3.7	3.5–4.5
IMPDH1(595)-Y12A	473	462–492	4.5	4.2–5.5
IMPDH1(595)-Y12A-S477D	464	458–486	4.1	3.9–5.0
IMPDH1(546)-WT	757	725–792	4.6	3.9–5.7
IMPDH1(546)-S477D	486	452–524	3.7	3.0–4.9
IMPDH1(546)-Y12A	538	505–575	4.0	3.3–5.3
IMPDH1(546)-Y12A-S477D	458	450–480	4.2	4.0–5.1