Isochronal kinetics: Mean V1/2 of activation (mV) and slope values (k, mV) for experimental data, and data from different models
| Construct . | G-V, V1/2, k (mV) . | F1-V, V1/2, k (mV) . | F2-V, V1/2, k (mV) . | n, G-V, F-V . |
|---|---|---|---|---|
| KCNQ1 | −33.9 ± 0.51, 7.6 ± 0.24 | - | - | 3 |
| EQ | 13.2 ± 3.9, 13.5 ± 1.2 | - | - | 8 |
| EQ*Q+E1 | 22.3 ± 1.9, 16.8 ± 0.77 | - | - | 5 |
| EQ*QQ*Q*+E1 | 32.8 ± 5.7, 19.4 ± 1.2 | - | - | 5 |
| psQ+E1 G-V | 4.19 ± 2.6, 17.4 ± 1.3 | −96.9 ± 2.0, 26.2 ± 1.0 | 3.0 ± 5.1, 18.6 ± 2.4 | 14, 8 |
| psQQ+E1 G-V | 7.06 ± 2.5, 15.2 ± 1.5 | −88.2 ± 5.1, 29.4 ± 2.8 | 3.2 ± 1.8, 15.0 ± 2.4 | 10,3 |
| psQQ*+E1 G-V | 23.5 ± 1.3, 16.2 ± 0.70 | −86.5 ± 4.2, 28.2 ± 2.4 | 21.0 ± 4.7, 18.0 ± 2.8 | 13, 8 |
| Model | G-V, V1/2, k (mV) | F1-V, V1/2, k (mV) | F2-V, V1/2, k (mV) | |
| 1 A | 62.5, 10.0 | - | - | |
| 1 B | 50.2, 13.2 | - | - | |
| 1 C | 33.5, 18.2 | - | - | |
| 2 A | 4.76, 20.6 | −99.6, 30 | 3.6, 20.4 | |
| 2 B | 23.2, 19.0 | −88.2, 30 | 26.0, 17.1 | |
| 4 A | 4.51, 21.4 | −95.5, 29.6 | 5.8, 18.9 | |
| 4 B | 22.0, 22.9 | −93.9, 30.2 | 22.4, 19.5 | |
| 4 C | 31.0, 23.3 | - | - | |
| 5 A | 7.5, 17.5 | −102, 28.6 | 2.93, 21.3 | |
| 5 B | 20.6, 19.3 | −101.9, 28.7 | 16.4, 24.7 | |
| 5 C | 33.8, 20.0 | - | - |
| Construct . | G-V, V1/2, k (mV) . | F1-V, V1/2, k (mV) . | F2-V, V1/2, k (mV) . | n, G-V, F-V . |
|---|---|---|---|---|
| KCNQ1 | −33.9 ± 0.51, 7.6 ± 0.24 | - | - | 3 |
| EQ | 13.2 ± 3.9, 13.5 ± 1.2 | - | - | 8 |
| EQ*Q+E1 | 22.3 ± 1.9, 16.8 ± 0.77 | - | - | 5 |
| EQ*QQ*Q*+E1 | 32.8 ± 5.7, 19.4 ± 1.2 | - | - | 5 |
| psQ+E1 G-V | 4.19 ± 2.6, 17.4 ± 1.3 | −96.9 ± 2.0, 26.2 ± 1.0 | 3.0 ± 5.1, 18.6 ± 2.4 | 14, 8 |
| psQQ+E1 G-V | 7.06 ± 2.5, 15.2 ± 1.5 | −88.2 ± 5.1, 29.4 ± 2.8 | 3.2 ± 1.8, 15.0 ± 2.4 | 10,3 |
| psQQ*+E1 G-V | 23.5 ± 1.3, 16.2 ± 0.70 | −86.5 ± 4.2, 28.2 ± 2.4 | 21.0 ± 4.7, 18.0 ± 2.8 | 13, 8 |
| Model | G-V, V1/2, k (mV) | F1-V, V1/2, k (mV) | F2-V, V1/2, k (mV) | |
| 1 A | 62.5, 10.0 | - | - | |
| 1 B | 50.2, 13.2 | - | - | |
| 1 C | 33.5, 18.2 | - | - | |
| 2 A | 4.76, 20.6 | −99.6, 30 | 3.6, 20.4 | |
| 2 B | 23.2, 19.0 | −88.2, 30 | 26.0, 17.1 | |
| 4 A | 4.51, 21.4 | −95.5, 29.6 | 5.8, 18.9 | |
| 4 B | 22.0, 22.9 | −93.9, 30.2 | 22.4, 19.5 | |
| 4 C | 31.0, 23.3 | - | - | |
| 5 A | 7.5, 17.5 | −102, 28.6 | 2.93, 21.3 | |
| 5 B | 20.6, 19.3 | −101.9, 28.7 | 16.4, 24.7 | |
| 5 C | 33.8, 20.0 | - | - |
First 4 data rows are from tsA201 cells; rows 5–7 are from oocytes; values in rows 9–19 are from simulations. For Scheme 1, A and B, G-V values are predictions using Eq. 2 (Fig. 1 D).