Sequence alignment of helices in the pore domain of calcium channelsa
| Channel . | Repeat . | Res # . | S4–S5 . | ∼ . | S5 . | ||
|---|---|---|---|---|---|---|---|
| k1 . | k11 . | o1 . | o11 . | o21 . | |||
| CavAb | VPQMRKIVSA | LI | SVIPGMLSVI | ALMTLFFYIF | AIMATQLFG | ||
| Cav1.1 | I | --SLQVVLNS | IF | KAMLPLFHIA | L-VLFMVI-Y | --IGLE--K | |
| Cav1.2 | I | 251 | ---------- | -I | ------L--- | -----VI--- | -------M- |
| Cav1.1 | II | WT-- SNLVA- | LL | NSIRSIASLL | --LFLF--- | F-LL-MQ-FG | |
| Cav1.2 | II | 635 | -N-------- | -- | --V------- | ---------- | S-------- |
| Cav1.1 | III | AKG-KHVVQC | VF | VAI-T-GNIV | -VTT-LQFM- | ACI-VQL-K | |
| Cav1.2 | III | 1,032 | ---------- | -- | ---------- | I--------- | --------- |
| Cav1.1 | IV | -E-VRTLLWT | FI | KSFQALPYVA | -LIVMLF-IY | -VI-MQM-G | |
| Cav1.2 | IV | 1,391 | G--I------ | -- | ---------- | ---------- | ------V-G |
| ∼∼======== P1 =====∼∼∼ | == P2 === | ||||||
| p34 | p41 | p51 | |||||
| CavAb | GTLGESF | YTLFQVMTLD | DWSMGIVRP | ||||
| Cav1.1 | I | DNF---M | L-VY-CI-ME | G-TDVLYWV | |||
| Cav1.2 | I | 346 | ---A-A- | ---F------ | --------- | ||
| Cav1.1 | II | ---PQ-L | IS---VL-G- | D-NS-M-NG | |||
| Cav1.2 | II | 689 | -----S- | LT---I---- | -------D- | ||
| Cav1.1 | III | DNVLSAM | MSLFTVS-F- | G-PQLLYRA | |||
| Cav1.2 | III | 1,118 | ----A-- | -A-------- | ---E----S | ||
| Cav1.1 | IV | QTFPQAV | LLLFRCA-G- | A-QEILLAC | |||
| Cav1.2 | IV | 1,447 | ------- | ---------- | ---D-M--- | ||
| =============== S6 ========================= | |||||||
| i1 | i11 | i21 | i31 | ||||
| CavAb | PYAWVFFIPF | IFVVTFVMIN | LVVAICVDAM | ILNQKEE | |||
| Cav1.1 | I | EWP-IY-VTL | -LLGS-FIL- | --LGVLSGEF | TKEREKA | ||
| Cav1.2 | I | 379 | D--------- | -------V-- | ---------- | S------ | |
| Cav1.1 | II | VLVC---II- | FVC-NYIL-- | VF-AIAVDNL | AEAESLT | ||
| Cav1.2 | II | 727 | M--------- | -I-------- | ---------- | -D----- | |
| Cav1.1 | III | VEMA-FF--Y | I-LIAFFMM- | I-VGFVIVTF | QEQGETE | ||
| Cav1.2 | III | 1,160 | --IS------ | --I------- | ---------- | -----Q- | |
| Cav1.1 | IV | NFAYYY--SF | YMLCAFLIIN | LFVAVIMDN- | DYLTRDW | ||
| Cav1.2 | IV | 1,498 | S--VF----- | ---------- | ---------- | ------- | |
| Channel . | Repeat . | Res # . | S4–S5 . | ∼ . | S5 . | ||
|---|---|---|---|---|---|---|---|
| k1 . | k11 . | o1 . | o11 . | o21 . | |||
| CavAb | VPQMRKIVSA | LI | SVIPGMLSVI | ALMTLFFYIF | AIMATQLFG | ||
| Cav1.1 | I | --SLQVVLNS | IF | KAMLPLFHIA | L-VLFMVI-Y | --IGLE--K | |
| Cav1.2 | I | 251 | ---------- | -I | ------L--- | -----VI--- | -------M- |
| Cav1.1 | II | WT-- SNLVA- | LL | NSIRSIASLL | --LFLF--- | F-LL-MQ-FG | |
| Cav1.2 | II | 635 | -N-------- | -- | --V------- | ---------- | S-------- |
| Cav1.1 | III | AKG-KHVVQC | VF | VAI-T-GNIV | -VTT-LQFM- | ACI-VQL-K | |
| Cav1.2 | III | 1,032 | ---------- | -- | ---------- | I--------- | --------- |
| Cav1.1 | IV | -E-VRTLLWT | FI | KSFQALPYVA | -LIVMLF-IY | -VI-MQM-G | |
| Cav1.2 | IV | 1,391 | G--I------ | -- | ---------- | ---------- | ------V-G |
| ∼∼======== P1 =====∼∼∼ | == P2 === | ||||||
| p34 | p41 | p51 | |||||
| CavAb | GTLGESF | YTLFQVMTLD | DWSMGIVRP | ||||
| Cav1.1 | I | DNF---M | L-VY-CI-ME | G-TDVLYWV | |||
| Cav1.2 | I | 346 | ---A-A- | ---F------ | --------- | ||
| Cav1.1 | II | ---PQ-L | IS---VL-G- | D-NS-M-NG | |||
| Cav1.2 | II | 689 | -----S- | LT---I---- | -------D- | ||
| Cav1.1 | III | DNVLSAM | MSLFTVS-F- | G-PQLLYRA | |||
| Cav1.2 | III | 1,118 | ----A-- | -A-------- | ---E----S | ||
| Cav1.1 | IV | QTFPQAV | LLLFRCA-G- | A-QEILLAC | |||
| Cav1.2 | IV | 1,447 | ------- | ---------- | ---D-M--- | ||
| =============== S6 ========================= | |||||||
| i1 | i11 | i21 | i31 | ||||
| CavAb | PYAWVFFIPF | IFVVTFVMIN | LVVAICVDAM | ILNQKEE | |||
| Cav1.1 | I | EWP-IY-VTL | -LLGS-FIL- | --LGVLSGEF | TKEREKA | ||
| Cav1.2 | I | 379 | D--------- | -------V-- | ---------- | S------ | |
| Cav1.1 | II | VLVC---II- | FVC-NYIL-- | VF-AIAVDNL | AEAESLT | ||
| Cav1.2 | II | 727 | M--------- | -I-------- | ---------- | -D----- | |
| Cav1.1 | III | VEMA-FF--Y | I-LIAFFMM- | I-VGFVIVTF | QEQGETE | ||
| Cav1.2 | III | 1,160 | --IS------ | --I------- | ---------- | -----Q- | |
| Cav1.1 | IV | NFAYYY--SF | YMLCAFLIIN | LFVAVIMDN- | DYLTRDW | ||
| Cav1.2 | IV | 1,498 | S--VF----- | ---------- | ---------- | ------- | |
Labels, which are universal for P-loop channels, are shown above respective segments. Characters k, o, p, and i stand, respectively, for the linker helices, outer helices, P-loops, and inner helices.