Table 1.

Serological parameters of MC4R-KO and WT mice treated with βCD-PRX for 6 wk

WT/SDMC/WD
ContContPRX
TG (mg/dl) 112.5 ± 1.8 120.1 ± 8.8 134.4 ± 16.5 
TC (mg/dl) 93.7 ±4.4 351.3 ± 20.0** 317.3 ± 18.2** 
ALT (U/liter) 35.8 ± 1.8 287.9 ± 38.3** 173.9 ± 34.1**# 
Insulin (ng/ml) 0.4 ± 0.1 33.6 ± 11.9* 23.0 ± 7.9 
WT/SDMC/WD
ContContPRX
TG (mg/dl) 112.5 ± 1.8 120.1 ± 8.8 134.4 ± 16.5 
TC (mg/dl) 93.7 ±4.4 351.3 ± 20.0** 317.3 ± 18.2** 
ALT (U/liter) 35.8 ± 1.8 287.9 ± 38.3** 173.9 ± 34.1**# 
Insulin (ng/ml) 0.4 ± 0.1 33.6 ± 11.9* 23.0 ± 7.9 

MC, MC4R-KO mice; Cont, control; PRX, βCD-PRX; TC, total cholesterol. WT/SD-Cont, n = 6; MC/WD-Cont, n = 9; MC/WD-PRX, n = 8. **P < 0.01 versus WT/SD-Cont; #P < 0.05 versus MC/WD-Cont. Data are representative of two independent experiments. Data are expressed as the mean ± SEM.

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