Serological parameters of MC4R-KO and WT mice treated with βCD-PRX for 6 wk
| WT/SD | MC/WD | ||
|---|---|---|---|
| Cont | Cont | PRX | |
| TG (mg/dl) | 112.5 ± 1.8 | 120.1 ± 8.8 | 134.4 ± 16.5 |
| TC (mg/dl) | 93.7 ±4.4 | 351.3 ± 20.0** | 317.3 ± 18.2** |
| ALT (U/liter) | 35.8 ± 1.8 | 287.9 ± 38.3** | 173.9 ± 34.1**# |
| Insulin (ng/ml) | 0.4 ± 0.1 | 33.6 ± 11.9* | 23.0 ± 7.9 |
| WT/SD | MC/WD | ||
|---|---|---|---|
| Cont | Cont | PRX | |
| TG (mg/dl) | 112.5 ± 1.8 | 120.1 ± 8.8 | 134.4 ± 16.5 |
| TC (mg/dl) | 93.7 ±4.4 | 351.3 ± 20.0** | 317.3 ± 18.2** |
| ALT (U/liter) | 35.8 ± 1.8 | 287.9 ± 38.3** | 173.9 ± 34.1**# |
| Insulin (ng/ml) | 0.4 ± 0.1 | 33.6 ± 11.9* | 23.0 ± 7.9 |
MC, MC4R-KO mice; Cont, control; PRX, βCD-PRX; TC, total cholesterol. WT/SD-Cont, n = 6; MC/WD-Cont, n = 9; MC/WD-PRX, n = 8. **P < 0.01 versus WT/SD-Cont; #P < 0.05 versus MC/WD-Cont. Data are representative of two independent experiments. Data are expressed as the mean ± SEM.