Table 7.

Volumes and surface areas of the different compartments considered in the model

PropertyMito 1Mito 2Mito 4Mito 5Mito 8Mito 9Mito 10Mito 11Mito 12
OM vol (µm3) 0.037 0.029 0.012 0.012 0.014 0.006 0.016 0.009 0.021 
IM vol (µm3) 0.016 0.010 0.005 0.004 0.006 0.002 0.008 0.003 0.010 
IM SA (µm2) 1.545 1.104 0.505 0.390 0.508 0.224 0.605 0.314 0.806 
High curva IM SA (µm2) 0.087 0.049 0.037 0.015 0.042 0.032 0.067 0.023 0.115 
Cyto vol (µm3) 0.306 0.061 0.094 0.048 0.101 0.050 0.108 0.111 0.148 
#ATPsyn 267 150 114 46 129 98 204 72 353 
#ANTs 16,471 10,294 5,398 4,118 6,177 2,570 7,905 3,578 10,294 
#VDACs 6,340 5,990 2,816 3,370 3,560 1,788 3,126 2,558 3,970 

These measurements were taken from nine realistic 3-D reconstructions of presynaptic and axonal mitochondria (Mendelsohn et al., 2021). The volume of the cytosol (Cyto vol) is an arbitrary volume. The numbers of proteins considered for each simulation were determined using the densities (Tables 2, 4, and 6) and respective surface areas or volumes. To determine the number of ATP synthases, the areas of high curvature (Mendelsohn et al., 2021) were considered (high curva IM SA), and values of the first principal curvature larger than 70 µm−1 were assessed.

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