Table 7. Volumes and surface areas of... | Rockefeller University Press

Table 7.

Volumes and surface areas of the different compartments considered in the model

Property	Mito 1	Mito 2	Mito 4	Mito 5	Mito 8	Mito 9	Mito 10	Mito 11	Mito 12
OM vol (µm³)	0.037	0.029	0.012	0.012	0.014	0.006	0.016	0.009	0.021
IM vol (µm³)	0.016	0.010	0.005	0.004	0.006	0.002	0.008	0.003	0.010
IM SA (µm²)	1.545	1.104	0.505	0.390	0.508	0.224	0.605	0.314	0.806
High curva IM SA (µm²)	0.087	0.049	0.037	0.015	0.042	0.032	0.067	0.023	0.115
Cyto vol (µm³)	0.306	0.061	0.094	0.048	0.101	0.050	0.108	0.111	0.148
#ATP_syn	267	150	114	46	129	98	204	72	353
#ANTs	16,471	10,294	5,398	4,118	6,177	2,570	7,905	3,578	10,294
#VDACs	6,340	5,990	2,816	3,370	3,560	1,788	3,126	2,558	3,970

Property	Mito 1	Mito 2	Mito 4	Mito 5	Mito 8	Mito 9	Mito 10	Mito 11	Mito 12
OM vol (µm³)	0.037	0.029	0.012	0.012	0.014	0.006	0.016	0.009	0.021
IM vol (µm³)	0.016	0.010	0.005	0.004	0.006	0.002	0.008	0.003	0.010
IM SA (µm²)	1.545	1.104	0.505	0.390	0.508	0.224	0.605	0.314	0.806
High curva IM SA (µm²)	0.087	0.049	0.037	0.015	0.042	0.032	0.067	0.023	0.115
Cyto vol (µm³)	0.306	0.061	0.094	0.048	0.101	0.050	0.108	0.111	0.148
#ATP_syn	267	150	114	46	129	98	204	72	353
#ANTs	16,471	10,294	5,398	4,118	6,177	2,570	7,905	3,578	10,294
#VDACs	6,340	5,990	2,816	3,370	3,560	1,788	3,126	2,558	3,970

These measurements were taken from nine realistic 3-D reconstructions of presynaptic and axonal mitochondria (Mendelsohn et al., 2021). The volume of the cytosol (Cyto vol) is an arbitrary volume. The numbers of proteins considered for each simulation were determined using the densities (Tables 2, 4, and 6) and respective surface areas or volumes. To determine the number of ATP synthases, the areas of high curvature (Mendelsohn et al., 2021) were considered (high curva IM SA), and values of the first principal curvature larger than 70 µm⁻¹ were assessed.

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