Table 2. Parameters for the ATP synthase... | Rockefeller University Press

Table 2.

Parameters for the ATP synthase model

Parameter	Definition	Value	Unit	Reference
F	Faraday’s constant	9.649 × 10⁴	C mol⁻¹	Keener and Sneyd (1998)
R	Universal gas constant	8.315	J mol⁻¹ K⁻¹	Keener and Sneyd (1998)
pH_m	Matrix pH	7.6		Magnus and Keizer (1997)
pH_c	Cristae pH	7.2		Magnus and Keizer (1997)
[Pi]	Phosphate concentration	20	mM	Pietrobon and Caplan (1985)
T	Temperature	310	K
K	Equilibrium constant	1.71 × 10⁶	M	Pietrobon and Caplan (1985)
Δψ	Membrane potential	180	mV	Holmuhamedov et al. (1998)
Δψ_B,i	Phase boundary potential	−50	mV	Pietrobon and Caplan (1985)
Δψ_B,M	Phase boundary potential	0	mV	Pietrobon and Caplan (1985)
k₆₁_,0	Rate constant at 0 mV	4.98 × 10⁷	s⁻¹	Pietrobon and Caplan (1985)
k_16,0	Rate constant at 0 mV	1 × 10²	s⁻¹	Pietrobon and Caplan (1985)
k_56,0	Rate constant at 0 mV	2.75 × 10⁵	s⁻¹	Pietrobon and Caplan (1985)
k_21,0	Rate constant at 0 mV	40	s⁻¹	Pietrobon and Caplan (1985)
$k_{43}^{*}$	Rate constant^{^b}	1 × 10⁸	M⁻² s⁻¹	Pietrobon and Caplan (1985)
$k_{12}^{*}$	Rate constant^{^b}	6.33 × 10²⁴	M⁻³ s⁻¹	Pietrobon and Caplan (1985)
$k_{65}^{*}$	Rate constant^{^b}	1.58 × 10²⁵	M⁻³ s⁻¹	Pietrobon and Caplan (1985)
$k_{23}^{*}$	Rate constant^{^b}	5 × 10⁶	M⁻¹ s⁻¹	Pietrobon and Caplan (1985)
k₅₄	Rate constant	1 × 10²	s⁻¹	Pietrobon and Caplan (1985)
k₃₂	Rate constant	5 × 10³	s⁻¹	Pietrobon and Caplan (1985)
k₃₄	Rate constant	100	s⁻¹	Pietrobon and Caplan (1985)
k₄₅	Rate constant	100	s⁻¹	Pietrobon and Caplan (1985)
k₅₆	Rate constant	1,000	s⁻¹	Pietrobon and Caplan (1985)
k₂₅	Rate constant	5.85 × 10⁻³⁰	s⁻¹	Pietrobon and Caplan (1985)
k₅₂	Rate constant	1 × 10⁻²⁰	s⁻¹	Pietrobon and Caplan (1985)
k₄₃	Rate constant^{^c}	2 × 10⁶	M⁻¹ s⁻¹	Pietrobon and Caplan (1985)
k₁₂	Rate constant^{^c}	25	s⁻¹	Pietrobon and Caplan (1985)
k₆₅	Rate constant^{^c}	3,969	s⁻¹	Pietrobon and Caplan (1985)
k₆₁	Rate constant at 180 mV	33,989	s⁻¹	Pietrobon and Caplan (1985)
k₁₆	Rate constant at 180 mV	146,516	s⁻¹	Pietrobon and Caplan (1985)
k₅₆	Rate constant at 180 mV	1,000	s⁻¹	Pietrobon and Caplan (1985)
k₂₁	Rate constant at 180 mV	40	s⁻¹	Pietrobon and Caplan (1985)
δ_atp	Density of ATP synthases	3,070	µm⁻²	Acehan et al. (2011)
#ATP_syn1	Number of ATP synthases for Mito #1	267		^{^a}

Parameter	Definition	Value	Unit	Reference
F	Faraday’s constant	9.649 × 10⁴	C mol⁻¹	Keener and Sneyd (1998)
R	Universal gas constant	8.315	J mol⁻¹ K⁻¹	Keener and Sneyd (1998)
pH_m	Matrix pH	7.6		Magnus and Keizer (1997)
pH_c	Cristae pH	7.2		Magnus and Keizer (1997)
[Pi]	Phosphate concentration	20	mM	Pietrobon and Caplan (1985)
T	Temperature	310	K
K	Equilibrium constant	1.71 × 10⁶	M	Pietrobon and Caplan (1985)
Δψ	Membrane potential	180	mV	Holmuhamedov et al. (1998)
Δψ_B,i	Phase boundary potential	−50	mV	Pietrobon and Caplan (1985)
Δψ_B,M	Phase boundary potential	0	mV	Pietrobon and Caplan (1985)
k₆₁_,0	Rate constant at 0 mV	4.98 × 10⁷	s⁻¹	Pietrobon and Caplan (1985)
k_16,0	Rate constant at 0 mV	1 × 10²	s⁻¹	Pietrobon and Caplan (1985)
k_56,0	Rate constant at 0 mV	2.75 × 10⁵	s⁻¹	Pietrobon and Caplan (1985)
k_21,0	Rate constant at 0 mV	40	s⁻¹	Pietrobon and Caplan (1985)
$k_{43}^{*}$	Rate constant^b	1 × 10⁸	M⁻² s⁻¹	Pietrobon and Caplan (1985)
$k_{12}^{*}$	Rate constant^b	6.33 × 10²⁴	M⁻³ s⁻¹	Pietrobon and Caplan (1985)
$k_{65}^{*}$	Rate constant^b	1.58 × 10²⁵	M⁻³ s⁻¹	Pietrobon and Caplan (1985)
$k_{23}^{*}$	Rate constant^b	5 × 10⁶	M⁻¹ s⁻¹	Pietrobon and Caplan (1985)
k₅₄	Rate constant	1 × 10²	s⁻¹	Pietrobon and Caplan (1985)
k₃₂	Rate constant	5 × 10³	s⁻¹	Pietrobon and Caplan (1985)
k₃₄	Rate constant	100	s⁻¹	Pietrobon and Caplan (1985)
k₄₅	Rate constant	100	s⁻¹	Pietrobon and Caplan (1985)
k₅₆	Rate constant	1,000	s⁻¹	Pietrobon and Caplan (1985)
k₂₅	Rate constant	5.85 × 10⁻³⁰	s⁻¹	Pietrobon and Caplan (1985)
k₅₂	Rate constant	1 × 10⁻²⁰	s⁻¹	Pietrobon and Caplan (1985)
k₄₃	Rate constant^c	2 × 10⁶	M⁻¹ s⁻¹	Pietrobon and Caplan (1985)
k₁₂	Rate constant^c	25	s⁻¹	Pietrobon and Caplan (1985)
k₆₅	Rate constant^c	3,969	s⁻¹	Pietrobon and Caplan (1985)
k₆₁	Rate constant at 180 mV	33,989	s⁻¹	Pietrobon and Caplan (1985)
k₁₆	Rate constant at 180 mV	146,516	s⁻¹	Pietrobon and Caplan (1985)
k₅₆	Rate constant at 180 mV	1,000	s⁻¹	Pietrobon and Caplan (1985)
k₂₁	Rate constant at 180 mV	40	s⁻¹	Pietrobon and Caplan (1985)
δ_atp	Density of ATP synthases	3,070	µm⁻²	Acehan et al. (2011)
#ATP_syn1	Number of ATP synthases for Mito #1	267		^a

Our estimation, given the surface area of high curvature of the IM measured in the reconstruction (Mendelsohn et al., 2021).

Independent of the concentration.

Concentration dependent.

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