Table 2. Effects of PKA on V o at... | Rockefeller University Press

Table 2.

Effects of PKA on V_o at half-maximal activation

Animal group	Treatment	P/P_o	V_H (in ML s⁻¹)	V_L (in ML s⁻¹)
WT	Basal (4)	0.493 ± 0.017	2.0 ± 0.2	1.0 ± 0.1
	PKA (4)	0.551 ± 0.029	2.9 ± 0.2^a	1.9 ± 0.2^a
cTnI_Ala2	Basal (4)	0.585 ± 0.010	2.1 ± 0.2	1.0 ± 0.1
	PKA (4)	0.575 ± 0.010	3.1 ± 0.3^a	1.8 ± 0.1^a
cMyBP-C null	Basal (5)	0.558 ± 0.050	4.5 ± 0.2
	PKA (4)	0.572 ± 0.020	4.3 ± 0.1
tWT	Basal (5)	0.481 ± 0.038	2.0 ± 0.1	0.9 ± 0.1
	PKA (4)	0.512 ± 0.036	3.5 ± 0.2^a	1.8 ± 0.2^a
t3SA	Basal (6)	0.518 ± 0.036	2.2 ± 0.1	1.1 ± 0.1
	PKA (6)	0.526 ± 0.026	1.9 ± 0.2	1.1 ± 0.1
t3SD	Basal (6)	0.540 ± 0.042	3.1 ± 0.2	1.9 ± 0.2
	PKA (5)	0.542 ± 0.052	3.9 ± 0.2^a	1.9 ± 0.1

Animal group	Treatment	P/P_o	V_H (in ML s⁻¹)	V_L (in ML s⁻¹)
WT	Basal (4)	0.493 ± 0.017	2.0 ± 0.2	1.0 ± 0.1
	PKA (4)	0.551 ± 0.029	2.9 ± 0.2^a	1.9 ± 0.2^a
cTnI_Ala2	Basal (4)	0.585 ± 0.010	2.1 ± 0.2	1.0 ± 0.1
	PKA (4)	0.575 ± 0.010	3.1 ± 0.3^a	1.8 ± 0.1^a
cMyBP-C null	Basal (5)	0.558 ± 0.050	4.5 ± 0.2
	PKA (4)	0.572 ± 0.020	4.3 ± 0.1
tWT	Basal (5)	0.481 ± 0.038	2.0 ± 0.1	0.9 ± 0.1
	PKA (4)	0.512 ± 0.036	3.5 ± 0.2^a	1.8 ± 0.2^a
t3SA	Basal (6)	0.518 ± 0.036	2.2 ± 0.1	1.1 ± 0.1
	PKA (6)	0.526 ± 0.026	1.9 ± 0.2	1.1 ± 0.1
t3SD	Basal (6)	0.540 ± 0.042	3.1 ± 0.2	1.9 ± 0.2
	PKA (5)	0.542 ± 0.052	3.9 ± 0.2^a	1.9 ± 0.1

All values are expressed as mean ± SEM, with the number of trabecular preparations listed in parentheses.

P/P_o, relative Ca²⁺-activated force.

Significantly different from basal control.