Phloretin effect on urea and diffusional water permeability in human RBCs
| . | Pu . | SD . | n . | Inhibition . | Pd . | SD . | n . | Inhibition . |
|---|---|---|---|---|---|---|---|---|
| cm/s × 104 | % | cm/s × 103 | % | |||||
| Donor JBR control | 2.69 | ± 0.05 | 4 | − | 2.35 | ± 0.01 | 3 | − |
| Donor JBR phloretin | 0.015 | ± 0.0002 | 4 | 99.4 | 2.42 | ± 0.29 | 4 | n.s. |
| D36 control | 5.62 | ± 0.26 | 4 | − | 2.18 | ± 0.27 | 4 | − |
| D36 phloretin | 0.014 | ± 0.0001 | 4 | 99.8 | 2.37 | ± 0.16 | 4 | n.s. |
| . | Pu . | SD . | n . | Inhibition . | Pd . | SD . | n . | Inhibition . |
|---|---|---|---|---|---|---|---|---|
| cm/s × 104 | % | cm/s × 103 | % | |||||
| Donor JBR control | 2.69 | ± 0.05 | 4 | − | 2.35 | ± 0.01 | 3 | − |
| Donor JBR phloretin | 0.015 | ± 0.0002 | 4 | 99.4 | 2.42 | ± 0.29 | 4 | n.s. |
| D36 control | 5.62 | ± 0.26 | 4 | − | 2.18 | ± 0.27 | 4 | − |
| D36 phloretin | 0.014 | ± 0.0001 | 4 | 99.8 | 2.37 | ± 0.16 | 4 | n.s. |
Pu and Pd values were determined at 25°C, pH 7.2. The cells in the efflux experiments with phloretin were exposed to 0.5–0.8 mM phloretin both during the cell preparation and the efflux. The urea concentration was 1 mM. Not significant is marked n.s.