Table 2.

Urea and diffusional water permeability in human RBCs: Effect of thiourea and urea

PuSDnInhibitionPdSDnInhibition
 cm/s × 104   
Control 2.30 ± 0.15 − 2.45 ± 0.16 − 
+Thiourea 0.64a ± 0.15 72.2 2.37b ± 0.10 3.2 
+Urea 1.31c ± 0.03 43.0 2.29c ± 0.19 6.5 
PuSDnInhibitionPdSDnInhibition
 cm/s × 104   
Control 2.30 ± 0.15 − 2.45 ± 0.16 − 
+Thiourea 0.64a ± 0.15 72.2 2.37b ± 0.10 3.2 
+Urea 1.31c ± 0.03 43.0 2.29c ± 0.19 6.5 

Pu and Pd values were determined at 25°C, pH 7.2. The urea concentration was 1 mM.

a

30 mM thiourea.

b

500 mM thiourea.

c

500 M urea.

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