Table 2.

Summary of electrophysiological parameters determined for Nav1.7 and the two mutations Nav1.7/L823R and Nav1.7/I1461T

Nav1.7/WTNav1.7/L823RNav1.7/I1461T
 15°C 25°C 35°C 15°C 25°C 35°C 15°C 25°C 35°C 
Activation parameter          
V1/2(mV) −27.5 ± 0.7 −32.0 ± 0.5 −35.4 ± 0.5 −37.4 ± 0.6 −41.2 ± 0.5 −44.8 ± 0.8 −16.7 ± 0.7 −23.4 ± 0.6 −27.1 ± 0.6 
k 6.3 ± 0.2 4.5 ± 0.2 4.2 ± 0.2 10.6 ± 0.3 7.0 ± 0.2 6.3 ± 0.3 8.5 ± 0.2 7.0 ± 0.2 6.0 ± 0.2 
Time-to-peak (ms) 0.64 ± 0.01 0.38 ± 0.005 n.a. 0.71 ± 0.05 0.43 ± 0.01 n.a. 1.07 ± 0.06 0.47 ± 0.01 n.a. 
n 94 80 81 73 88 37 50 50 51 
Inactivation parameter          
V1/2(mV) −76.2 ± 0,9 −75.4 ± 0.5 −76.1 ± 0.7 −81.3 ± 0.4 −76.4 ± 0.5 −76.6 ± 0.9 −67.1 ± 0.7 −65.8 ± 0.8 −60.6 ± 0.8 
k −10.3 ± 0.3 −7.0 ± 0.1 −7.3 ± 0.1 −6.5 ± 0.2 −5.1 ± 0.1 −5.8 ± 0.2 −7.8 ± 0.2 −8.1 ± 0.2 −6.9 ± 0.2 
n 138 135 121 70 81 49 49 66 57 
Inactivation kinetics          
τ (ms) (0 mV) 1.13 0.53 0.28 1.47 0.60 0.35 2.73 0.70 0.33 
n 93 76 79 71 84 29 50 47 42 
Max Ipers(% from Imax) 2.5 ± 0.3 0.7 ± 0.1 n.a. 10.0 ± 0.4 3.8 ± 0.1 2.4 ± 0.4 14.4 ± 1.4 3.9 ± 0.6 1.8 ± 0.2 
n 94 76 81 73 84 37 50 48 51 
Recovery from fast inactivation          
% τ fast 87.0 81.4 51.0 86.4 87.3 56.9 78.4 51.3 31.7 
τ fast (ms) 49.2 13.3 8.5 89.0 20.0 11.0 22.4 8.34 589.2 
τ slow (ms) 447.8 428.8 621.9 403.4 315.4 550.1 337.3 523.5 589.2 
n 74 87 61 50 62 24 35 54 45 

n.a., not available.

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