Yeast proteins regulating PO abundancea and size
| . | ||||
|---|---|---|---|---|
| Proteins with dysferlin domains | Deletion phenotypes (in organism listed in the first column) | |||
| Protein | Ortholog | PO number in deletion strain | PO size/other in deletion strain | Reference |
| OpPex23 | YlPex23 | Reduced | Enhanced/most peroxisomal matrix proteins cytosolic | Wu et al. (2020) |
| OpPex24 | YlPex24, KpPex24 | Reduced | Enhanced | Wu et al. (2020) |
| Proteins with dysferlin and reticulon homology domains | Deletion phenotypes (in organism listed in the first column) | |||
| ScPex28 | Enhanced in oleate | Reduced and clustered in oleate | Vizeacoumar et al. (2003) | |
| ScPex29 | OpPex29, KpPex29 | Enhanced in oleate | Reduced and clustered in oleate | Mast et al. (2016); Vizeacoumar et al. (2003) |
| ScPex30 | KpPex30 | Enhanced in oleate; reduced upon PEX3 overexpression in galactose | Unchanged in oleate | David et al. (2013); Joshi et al. (2016); Mast et al. (2016); Vizeacoumar et al. (2004) |
| ScPex31 | KpPex31 | Unchanged in oleate; reduced upon PEX3 overexpression in galactose | Enhanced in oleate | Joshi et al. (2016); Mast et al. (2016); Vizeacoumar et al. (2004) |
| ScPex32 | OpPex32 | Unchanged in oleate | Enhanced in oleate | Vizeacoumar et al. (2004) |
| Other proteins | Deletion phenotypes (in organism listed in the first column) | |||
| ScPex35 | None reported | Reduced in glucose and oleate | Reduced in glucose | Yofe et al. (2017) |
| OpPex37 | HsPXMP2 | Reduced in glucose, not methanol | PO segregation defect only in glucose, not methanol | Singh et al. (2020) |
| . | ||||
|---|---|---|---|---|
| Proteins with dysferlin domains | Deletion phenotypes (in organism listed in the first column) | |||
| Protein | Ortholog | PO number in deletion strain | PO size/other in deletion strain | Reference |
| OpPex23 | YlPex23 | Reduced | Enhanced/most peroxisomal matrix proteins cytosolic | Wu et al. (2020) |
| OpPex24 | YlPex24, KpPex24 | Reduced | Enhanced | Wu et al. (2020) |
| Proteins with dysferlin and reticulon homology domains | Deletion phenotypes (in organism listed in the first column) | |||
| ScPex28 | Enhanced in oleate | Reduced and clustered in oleate | Vizeacoumar et al. (2003) | |
| ScPex29 | OpPex29, KpPex29 | Enhanced in oleate | Reduced and clustered in oleate | Mast et al. (2016); Vizeacoumar et al. (2003) |
| ScPex30 | KpPex30 | Enhanced in oleate; reduced upon PEX3 overexpression in galactose | Unchanged in oleate | David et al. (2013); Joshi et al. (2016); Mast et al. (2016); Vizeacoumar et al. (2004) |
| ScPex31 | KpPex31 | Unchanged in oleate; reduced upon PEX3 overexpression in galactose | Enhanced in oleate | Joshi et al. (2016); Mast et al. (2016); Vizeacoumar et al. (2004) |
| ScPex32 | OpPex32 | Unchanged in oleate | Enhanced in oleate | Vizeacoumar et al. (2004) |
| Other proteins | Deletion phenotypes (in organism listed in the first column) | |||
| ScPex35 | None reported | Reduced in glucose and oleate | Reduced in glucose | Yofe et al. (2017) |
| OpPex37 | HsPXMP2 | Reduced in glucose, not methanol | PO segregation defect only in glucose, not methanol | Singh et al. (2020) |
Hs, H. sapiens; Kp, K. phaffii; Mm, M. musculus; Op, O. polymorpha; Sc, S. cerevisiae.
PO abundance could occur by one or more of the following mechanisms—increased de novo PO biogenesis or PO division, or reduced pexophagy.