Table 3. Yeast proteins regulating PO... | Rockefeller University Press

Table 3.

Yeast proteins regulating PO abundance^{^a} and size


Proteins with dysferlin domains		Deletion phenotypes (in organism listed in the first column)
Protein	Ortholog	PO number in deletion strain	PO size/other in deletion strain	Reference
OpPex23	YlPex23	Reduced	Enhanced/most peroxisomal matrix proteins cytosolic	Wu et al. (2020)
OpPex24	YlPex24, KpPex24	Reduced	Enhanced	Wu et al. (2020)
Proteins with dysferlin and reticulon homology domains		Deletion phenotypes (in organism listed in the first column)
ScPex28		Enhanced in oleate	Reduced and clustered in oleate	Vizeacoumar et al. (2003)
ScPex29	OpPex29, KpPex29	Enhanced in oleate	Reduced and clustered in oleate	Mast et al. (2016); Vizeacoumar et al. (2003)
ScPex30	KpPex30	Enhanced in oleate; reduced upon PEX3 overexpression in galactose	Unchanged in oleate	David et al. (2013); Joshi et al. (2016); Mast et al. (2016); Vizeacoumar et al. (2004)
ScPex31	KpPex31	Unchanged in oleate; reduced upon PEX3 overexpression in galactose	Enhanced in oleate	Joshi et al. (2016); Mast et al. (2016); Vizeacoumar et al. (2004)
ScPex32	OpPex32	Unchanged in oleate	Enhanced in oleate	Vizeacoumar et al. (2004)
Other proteins		Deletion phenotypes (in organism listed in the first column)
ScPex35	None reported	Reduced in glucose and oleate	Reduced in glucose	Yofe et al. (2017)
OpPex37	HsPXMP2	Reduced in glucose, not methanol	PO segregation defect only in glucose, not methanol	Singh et al. (2020)


Proteins with dysferlin domains		Deletion phenotypes (in organism listed in the first column)
Protein	Ortholog	PO number in deletion strain	PO size/other in deletion strain	Reference
OpPex23	YlPex23	Reduced	Enhanced/most peroxisomal matrix proteins cytosolic	Wu et al. (2020)
OpPex24	YlPex24, KpPex24	Reduced	Enhanced	Wu et al. (2020)
Proteins with dysferlin and reticulon homology domains		Deletion phenotypes (in organism listed in the first column)
ScPex28		Enhanced in oleate	Reduced and clustered in oleate	Vizeacoumar et al. (2003)
ScPex29	OpPex29, KpPex29	Enhanced in oleate	Reduced and clustered in oleate	Mast et al. (2016); Vizeacoumar et al. (2003)
ScPex30	KpPex30	Enhanced in oleate; reduced upon PEX3 overexpression in galactose	Unchanged in oleate	David et al. (2013); Joshi et al. (2016); Mast et al. (2016); Vizeacoumar et al. (2004)
ScPex31	KpPex31	Unchanged in oleate; reduced upon PEX3 overexpression in galactose	Enhanced in oleate	Joshi et al. (2016); Mast et al. (2016); Vizeacoumar et al. (2004)
ScPex32	OpPex32	Unchanged in oleate	Enhanced in oleate	Vizeacoumar et al. (2004)
Other proteins		Deletion phenotypes (in organism listed in the first column)
ScPex35	None reported	Reduced in glucose and oleate	Reduced in glucose	Yofe et al. (2017)
OpPex37	HsPXMP2	Reduced in glucose, not methanol	PO segregation defect only in glucose, not methanol	Singh et al. (2020)

Hs, H. sapiens; Kp, K. phaffii; Mm, M. musculus; Op, O. polymorpha; Sc, S. cerevisiae.

PO abundance could occur by one or more of the following mechanisms—increased de novo PO biogenesis or PO division, or reduced pexophagy.

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