Table 2.

Regulation of dynamin-like proteins and their receptors/adaptors involved in PO and mitochondrial division via PTMs

Organelle-specific receptor/adaptor and rolePTMProtein implicated in PTMDirection of regulation of divisionProtein reversing PTMReferences
Pex11—peroxisomal division in yeast and mammals Phosphorylation of ScPex11-S165 and ScPex11-S167 PHO85 Positive Unknown Knoblach and Rachubinski (2010)  
ABHD16A—mammalian mitochondrial division Unknown    Nguyen and Voeltz (2022)  
Fis1/FIS1—peroxisomal and mitochondrial division in yeast and mammals Ubiquitination of HsFIS1 MARCH5 Positive  Yonashiro et al. (2006)  
MFF—peroxisomal and mitochondrial division in mammals Phosphorylation of MFF-S155,MFF-S172, MFF-S275 PKD1 Positive  Pangou et al. (2021)  
Phosphorylation of MFF-S155 and MFF-S172 AMPK Positive  Toyama et al. (2016)  
Ubiquitination of MFF (multiple sites) PARK2 Negative  Lee et al. (2019)  
MiD49/Mid51—mammalian mitochondrial division Ubiquitination of Mid49 MARCH5 Negative  Xu et al. (2016)  
INF2—mammalian mitochondrial division Farnesylation at C terminal C1270 Unknown Positive  Chhabra et al. (2009)  
Dynamin-related protein needed for membrane fission PTM Protein implicated in PTM Direction of regulation of division Protein reversing PTM Reference 
Dnm1/DRP1—yeast and mammalian peroxisomal and mitochondrial division Phosphorylation of HsDRP1- S616 CDK1, CDK5, PKCδ, PINK1, MAPK/ERK1,2, ROCK, CaMKIIα Positive DUSP6, Calcineurin, PP2A Che et al. (2022); Dickey and Strack (2011); Kashatus et al. (2015); Ma et al. (2020)  
Phosphorylation of HsDRP1- S637 PKA, CaMKIα, ROCK1, AMPK Negative PGAM5S Cereghetti et al. (2008); Cribbs and Strack (2007); Wang et al. (2012a); Wikstrom et al. (2013)  
Phosphorylation of HsDRP1- S693 GSK3β Negative  Chou et al. (2012)  
Ubiquitination MARCH5,
Parkin 		Positive  Karbowski et al. (2007); Wang et al. (2011); Wang et al. (2021)  
HsDRP1 SUMOylation (8 Lys in B domain) MAPL Positive SenP5 Braschi et al. (2009); Zunino et al. (2009)  
Ubp9 Positive  Figueroa-Romero et al. (2009); Harder et al. (2004)  
HsDRP1-C644 S-nitrosylation  Unknown  Cho et al. (2009)  
HsDRP1-T585,
HsDRP1-T586 and others, O-GlcNac 		OGT Positive  Akinbiyi et al. (2021)  
Vps1—yeast peroxisomal division N-terminal acetylation NatB Unknown  Jiang et al. (2022)  
ScVps1-S599 PHO85 Uninvolved  Smaczynska-de Rooij et al. (2015)  
DNM2—mammalian mitochondrial division Phosphorylation of HsDNM2-S764 CDK1 Unknown  Chircop et al. (2011)  
S-nitrosylation of HsDNM2-C86, HsDNM2-C607 NOSIII Unknown  Wang et al. (2012c)  
Organelle-specific receptor/adaptor and rolePTMProtein implicated in PTMDirection of regulation of divisionProtein reversing PTMReferences
Pex11—peroxisomal division in yeast and mammals Phosphorylation of ScPex11-S165 and ScPex11-S167 PHO85 Positive Unknown Knoblach and Rachubinski (2010)  
ABHD16A—mammalian mitochondrial division Unknown    Nguyen and Voeltz (2022)  
Fis1/FIS1—peroxisomal and mitochondrial division in yeast and mammals Ubiquitination of HsFIS1 MARCH5 Positive  Yonashiro et al. (2006)  
MFF—peroxisomal and mitochondrial division in mammals Phosphorylation of MFF-S155,MFF-S172, MFF-S275 PKD1 Positive  Pangou et al. (2021)  
Phosphorylation of MFF-S155 and MFF-S172 AMPK Positive  Toyama et al. (2016)  
Ubiquitination of MFF (multiple sites) PARK2 Negative  Lee et al. (2019)  
MiD49/Mid51—mammalian mitochondrial division Ubiquitination of Mid49 MARCH5 Negative  Xu et al. (2016)  
INF2—mammalian mitochondrial division Farnesylation at C terminal C1270 Unknown Positive  Chhabra et al. (2009)  
Dynamin-related protein needed for membrane fission PTM Protein implicated in PTM Direction of regulation of division Protein reversing PTM Reference 
Dnm1/DRP1—yeast and mammalian peroxisomal and mitochondrial division Phosphorylation of HsDRP1- S616 CDK1, CDK5, PKCδ, PINK1, MAPK/ERK1,2, ROCK, CaMKIIα Positive DUSP6, Calcineurin, PP2A Che et al. (2022); Dickey and Strack (2011); Kashatus et al. (2015); Ma et al. (2020)  
Phosphorylation of HsDRP1- S637 PKA, CaMKIα, ROCK1, AMPK Negative PGAM5S Cereghetti et al. (2008); Cribbs and Strack (2007); Wang et al. (2012a); Wikstrom et al. (2013)  
Phosphorylation of HsDRP1- S693 GSK3β Negative  Chou et al. (2012)  
Ubiquitination MARCH5,
Parkin 		Positive  Karbowski et al. (2007); Wang et al. (2011); Wang et al. (2021)  
HsDRP1 SUMOylation (8 Lys in B domain) MAPL Positive SenP5 Braschi et al. (2009); Zunino et al. (2009)  
Ubp9 Positive  Figueroa-Romero et al. (2009); Harder et al. (2004)  
HsDRP1-C644 S-nitrosylation  Unknown  Cho et al. (2009)  
HsDRP1-T585,
HsDRP1-T586 and others, O-GlcNac 		OGT Positive  Akinbiyi et al. (2021)  
Vps1—yeast peroxisomal division N-terminal acetylation NatB Unknown  Jiang et al. (2022)  
ScVps1-S599 PHO85 Uninvolved  Smaczynska-de Rooij et al. (2015)  
DNM2—mammalian mitochondrial division Phosphorylation of HsDNM2-S764 CDK1 Unknown  Chircop et al. (2011)  
S-nitrosylation of HsDNM2-C86, HsDNM2-C607 NOSIII Unknown  Wang et al. (2012c)  
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