Key proteins and their orthologs involved in peroxisomal and mitochondrial division
| Protein . | Ortholog . | Involved in peroxisomal (P), mitochondrial (M) division, or both (P/M) . | Function of protein . | Reference . |
|---|---|---|---|---|
| Organelle-specific adaptors | ||||
| ABHD16A | Unknown | M | Mitochondria-specific membrane constriction protein | Nguyen and Voeltz (2022) |
| PEX11-family adaptors | ||||
| ScPex11 | OpPex11, KpPex11, HsPEX11α, βa, γ | P | Peroxisome-specific adaptor required for membrane tubulation and elongation; acts as GAP for Dnm1 | Koch et al. (2010); Williams et al. (2015) |
| ScPex25 | KpPex25, OpPex25 | P | Tubulation of ER | Huber et al. (2012); Rottensteiner et al. (2003) |
| ScPex27 | KpPex11C, OpPex11C | P | Recruitment of ScVps1 | Ekal et al. (2023) |
| ScPex34 | KpPex36 | P | ScPex34 acts with the Pex11 family proteins to regulate the PO population | Tower et al. (2011) |
| Other adaptors | ||||
| ScCaf4 | P/M in yeast | Yeast adaptor for Dnm1 recruitment | Guo et al. (2012) | |
| ScMdv1 | P/M in yeast | Yeast adaptor for Dnm1 recruitment | Motley et al. (2008) | |
| ScFis1 | MmFIS1, HsFIS1 | P/M | Adaptor for Dnm1/DRP1 | Koch et al. (2005); Motley et al. (2008); Mozdy et al. (2000) |
| HsMiD49 | M | Mammalian adaptor for DNM1/DRP1 recruitment | Palmer et al. (2011) | |
| HsMiD51 | M | Mammalian adaptor for DNM1/DRP1 recruitment | Palmer et al. (2011) | |
| HsMFF | P/M | Mammalian adaptor for DNM1/DRP1 recruitment | Gandre-Babbe and van der Bliek (2008) | |
| HsINF2 | M | ER-localized formin protein required for actin recruitment | Chhabra et al. (2009); Korobova et al. (2013) | |
| Membrane scission GTPases | ||||
| ScVps1 | KpVps1, OpVps1 | P in yeast | GTPase required for organelle scission in glucose | Ekal et al. (2023); Kuravi et al. (2006) |
| ScDnm1 | KpDnm1, MmDNM1, HsDNM1 | P/M | GTPase required for organelle scission | Lee et al. (2016) |
| MmDNM2 | HsDNM2 | M in mammals | GTPase required for completion of organelle scission | Lee et al. (2016) |
| Accessory factors | ||||
| MmNME3 | HsNME3, C. merolae DYNAMO1 | P/M in mammals | Nucleoside diphosphate kinase | Honsho et al. (2020) |
| Protein . | Ortholog . | Involved in peroxisomal (P), mitochondrial (M) division, or both (P/M) . | Function of protein . | Reference . |
|---|---|---|---|---|
| Organelle-specific adaptors | ||||
| ABHD16A | Unknown | M | Mitochondria-specific membrane constriction protein | Nguyen and Voeltz (2022) |
| PEX11-family adaptors | ||||
| ScPex11 | OpPex11, KpPex11, HsPEX11α, βa, γ | P | Peroxisome-specific adaptor required for membrane tubulation and elongation; acts as GAP for Dnm1 | Koch et al. (2010); Williams et al. (2015) |
| ScPex25 | KpPex25, OpPex25 | P | Tubulation of ER | Huber et al. (2012); Rottensteiner et al. (2003) |
| ScPex27 | KpPex11C, OpPex11C | P | Recruitment of ScVps1 | Ekal et al. (2023) |
| ScPex34 | KpPex36 | P | ScPex34 acts with the Pex11 family proteins to regulate the PO population | Tower et al. (2011) |
| Other adaptors | ||||
| ScCaf4 | P/M in yeast | Yeast adaptor for Dnm1 recruitment | Guo et al. (2012) | |
| ScMdv1 | P/M in yeast | Yeast adaptor for Dnm1 recruitment | Motley et al. (2008) | |
| ScFis1 | MmFIS1, HsFIS1 | P/M | Adaptor for Dnm1/DRP1 | Koch et al. (2005); Motley et al. (2008); Mozdy et al. (2000) |
| HsMiD49 | M | Mammalian adaptor for DNM1/DRP1 recruitment | Palmer et al. (2011) | |
| HsMiD51 | M | Mammalian adaptor for DNM1/DRP1 recruitment | Palmer et al. (2011) | |
| HsMFF | P/M | Mammalian adaptor for DNM1/DRP1 recruitment | Gandre-Babbe and van der Bliek (2008) | |
| HsINF2 | M | ER-localized formin protein required for actin recruitment | Chhabra et al. (2009); Korobova et al. (2013) | |
| Membrane scission GTPases | ||||
| ScVps1 | KpVps1, OpVps1 | P in yeast | GTPase required for organelle scission in glucose | Ekal et al. (2023); Kuravi et al. (2006) |
| ScDnm1 | KpDnm1, MmDNM1, HsDNM1 | P/M | GTPase required for organelle scission | Lee et al. (2016) |
| MmDNM2 | HsDNM2 | M in mammals | GTPase required for completion of organelle scission | Lee et al. (2016) |
| Accessory factors | ||||
| MmNME3 | HsNME3, C. merolae DYNAMO1 | P/M in mammals | Nucleoside diphosphate kinase | Honsho et al. (2020) |
Cm, Cyanidioschyzon merolae; Hs, Homo sapiens; Kp, Komagataella phaffii (previously Pichia pastoris); Mm, Mus musculus; Op, O. polymorpha (previously Hansenula polymorpha); Sc, S. cerevisiae.
The PEX11β isoform, working with FIS1, plays a major role in PO division in mammals (Schrader et al., 2022).