Table 1.

Resting and active membrane properties of WT, Kv12.1−/−, Kv12.2−/−, and DKO (Kv12.1−/−/Kv12.2−/−) SCN neurons during the day and at night

Firing rate (Hz)Rin (GΩ)Vr (mV)ISI (ms)
Day ZT 7–12 WT 4.0 ± 0.5
n = 28 		1.7 ± 0.2**
n = 20 		−41.6 ± 0.7***
n = 28 		280 ± 9*
n = 28 
Kv12.1−/− 4.3 ± 0.6
n = 38 		2.0 ± 0.2
n = 33 		−40.4 ± 0.7
n = 38 		252 ± 9
n = 38 
Kv12.2−/− 3.6 ± 0.3
n = 35 		2.0 ± 0.1
n = 34 		−38.4 ± 0.7
n = 35 		311 ± 9
n = 35 
DKO 4.1 ± 0.3
n = 6 		1.6 ± 0.2
n = 6 		−40.8 ± 1.6
n = 6 		279 ± 13
n = 6 
Night ZT 18–24 WT 0.8 ± 0.2*
n = 25 		1.0 ± 0.1**
n = 24 		−46.7 ± 1.0***
n = 25 		418 ± 29*
n = 20 
Kv12.1−/− 4.0 ± 0.7
n = 21 		1.8 ± 0.2
n = 18 		−37.7 ± 1.2
n = 21 		254 ± 6
n = 21 
Kv12.2−/− 3.1 ± 0.5
n = 22 		2.0 ± 0.2
n = 22 		−37.5 ± 0.9
n = 22 		319 ± 17
n = 22 
DKO 3.4 ± 0.4
n = 6 		1.5 ± 0.2
n = 6 		−40.5 ± 3.2
n = 6 		318 ± 12
n = 6 
Firing rate (Hz)Rin (GΩ)Vr (mV)ISI (ms)
Day ZT 7–12 WT 4.0 ± 0.5
n = 28 		1.7 ± 0.2**
n = 20 		−41.6 ± 0.7***
n = 28 		280 ± 9*
n = 28 
Kv12.1−/− 4.3 ± 0.6
n = 38 		2.0 ± 0.2
n = 33 		−40.4 ± 0.7
n = 38 		252 ± 9
n = 38 
Kv12.2−/− 3.6 ± 0.3
n = 35 		2.0 ± 0.1
n = 34 		−38.4 ± 0.7
n = 35 		311 ± 9
n = 35 
DKO 4.1 ± 0.3
n = 6 		1.6 ± 0.2
n = 6 		−40.8 ± 1.6
n = 6 		279 ± 13
n = 6 
Night ZT 18–24 WT 0.8 ± 0.2*
n = 25 		1.0 ± 0.1**
n = 24 		−46.7 ± 1.0***
n = 25 		418 ± 29*
n = 20 
Kv12.1−/− 4.0 ± 0.7
n = 21 		1.8 ± 0.2
n = 18 		−37.7 ± 1.2
n = 21 		254 ± 6
n = 21 
Kv12.2−/− 3.1 ± 0.5
n = 22 		2.0 ± 0.2
n = 22 		−37.5 ± 0.9
n = 22 		319 ± 17
n = 22 
DKO 3.4 ± 0.4
n = 6 		1.5 ± 0.2
n = 6 		−40.5 ± 3.2
n = 6 		318 ± 12
n = 6 

Values are means ± SEM; n = number of cells; Rin = input resistance; Vr = resting membrane potentials; ISI = interspike interval. Values in daytime and nighttime WT neurons are significantly different (*P = 0.0001; **P = 0.02; ***P = 0.0005).

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