Table II.

Summary of the effects of the different XPD mutations

   XPD mutation 
   R683W Q452X I455del 199insPP 
DNA repair NER 
 helicase activity ±    
 ATPase + + + + 
 TFIIH structure 50 mM KCl + + + + 
  150 mM KCl + + +  
 p44–XPD interaction 350 mM KCl +  +  
Transcription RNA pol II phosphorylation + ±   
 cdk7 kinase activity + + +  
 basal transcription +    
 transactivation by nuclear receptors 
 nuclear receptor stabilization + + + ± 
   XPD mutation 
   R683W Q452X I455del 199insPP 
DNA repair NER 
 helicase activity ±    
 ATPase + + + + 
 TFIIH structure 50 mM KCl + + + + 
  150 mM KCl + + +  
 p44–XPD interaction 350 mM KCl +  +  
Transcription RNA pol II phosphorylation + ±   
 cdk7 kinase activity + + +  
 basal transcription +    
 transactivation by nuclear receptors 
 nuclear receptor stabilization + + + ± 
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