Membrane proteins that are modified by the TZDs
| TZD | PPARγ EC50a | Off-target and effect | EC50b | Reference |
| µM | µM | |||
| Troglitazone | 0.5 | ATP-sensitive potassium channel KATP | 0.7 | Lee et al., 1996 |
| L-type calcium channels | 3–4 | Nakamura et al., 1998 | ||
| Ca2+-activated potassium channel BKCa | 20–30c | Knock et al., 1999; Stowers et al., 2000 | ||
| Delayed rectifier potassium channel Kv1.3 | 3 | Ahn et al., 2007 | ||
| Acute glucose transport | 3c | Preininger et al., 1999 | ||
| Na+/H+ exchange | 10c | de Dios et al., 2001 | ||
| Bile transport (bile salt export pump) | 4 10c | Funk et al., 2001; Snow and Moseley, 2007 | ||
| Rosiglitazone | 0.06–0.09 | Voltage-dependent Ca2+ current | 2c | Knock et al., 1999 |
| Ca2+-activated potassium channels, BKCa | 20c | Knock et al., 1999; Stowers et al., 2000 | ||
| Delayed rectifier potassium channel Kv1.3 | 18 | Ahn et al., 2007 | ||
| Bile transport | 10c | Snow and Moseley, 2007 | ||
| Pioglitazone | 0.6 | L-type calcium channels | 45 | Nakamura et al., 1998 |
| Ciglitazone | 3–23 | Ca2+-activated potassium channel BKCa | 16 | Stowers et al., 2000 |
| Store-operated calcium+ channels | 30c | Kim et al., 2005; Epshtein et al., 2009 | ||
| Bile transport | 5c | Snow and Moseley, 2007 |
| TZD | PPARγ EC50a | Off-target and effect | EC50b | Reference |
| µM | µM | |||
| Troglitazone | 0.5 | ATP-sensitive potassium channel KATP | 0.7 | Lee et al., 1996 |
| L-type calcium channels | 3–4 | Nakamura et al., 1998 | ||
| Ca2+-activated potassium channel BKCa | 20–30c | Knock et al., 1999; Stowers et al., 2000 | ||
| Delayed rectifier potassium channel Kv1.3 | 3 | Ahn et al., 2007 | ||
| Acute glucose transport | 3c | Preininger et al., 1999 | ||
| Na+/H+ exchange | 10c | de Dios et al., 2001 | ||
| Bile transport (bile salt export pump) | 4 10c | Funk et al., 2001; Snow and Moseley, 2007 | ||
| Rosiglitazone | 0.06–0.09 | Voltage-dependent Ca2+ current | 2c | Knock et al., 1999 |
| Ca2+-activated potassium channels, BKCa | 20c | Knock et al., 1999; Stowers et al., 2000 | ||
| Delayed rectifier potassium channel Kv1.3 | 18 | Ahn et al., 2007 | ||
| Bile transport | 10c | Snow and Moseley, 2007 | ||
| Pioglitazone | 0.6 | L-type calcium channels | 45 | Nakamura et al., 1998 |
| Ciglitazone | 3–23 | Ca2+-activated potassium channel BKCa | 16 | Stowers et al., 2000 |
| Store-operated calcium+ channels | 30c | Kim et al., 2005; Epshtein et al., 2009 | ||
| Bile transport | 5c | Snow and Moseley, 2007 |