Model-dependent parameters resulting from fit of GV curves
| Basic open-channel block | ||||
| Scheme 1 | Scheme 1a | |||
| Kbo (µM) | 5.90 ± 0.40 | |||
| zc | 0.13 ± 0.02 e | |||
| Kbc (µM) | ||||
| zc | ||||
| SSQ | 395.95 | |||
| State-independent closed- and open-channel block and variations | ||||
| Scheme 2 | Scheme 2a | Scheme 2a′ | Scheme 2b | Scheme 2b′ |
| Kbo (µM) | 7.42 ± 0.43 | 6.01 ± 0.30 | 6.96 ± 0.39 | 6.36 ± 0.45 |
| zc | 0.17 ± 0.02 e | 0.10 ± 0.02 e | 0.15 ± 0.2 e | 0.15 ± 0.02 e |
| Kbc (µM) | =Kbo | 45.79 ± 35.9 | =Kbo | 21.4 ± 12.2 |
| zc | =zc | 0.81 ± 0.20 e | 0.0* | 0.0* |
| SSQ | 309.199 | 100.66 | 486.663 | 326.09 |
| Block dependent on movement of one voltage sensor | ||||
| Scheme 3 | Scheme 3a | Scheme 3a′ | Scheme 3b | Scheme 3b′ |
| Kbo (µM) | 6.14 ± 0.26 | 6.01 ± 0.27 | 6.02 ± 0.29 | 6.48 ± 0.29 |
| zo | 0.13 ± 0.01 e | 0.10 ± 0.02 e | 0.13 ± 0.02 e | 0.13 ± 0.01 e |
| Kbc (µM) | =Kbo | 8.1 ± 6.7 | =Kbo | 2.34 ± 0.38 |
| zc | =zc | 0.44 ± 0.23 e | 0.0 | 0.0* |
| SSQ | 159.163 | 93.75 | 209.18 | 138.242 |
| Block scales with movement of each voltage sensor | ||||
| Scheme 4 | Scheme 4a′ | Scheme 4b′ | ||
| 4 Kbo (µM) | 19.53 ± 0.9 | 20.78 ± 0.80 | ||
| zo | 0.06 ± 0.02 e | 0.08 ± 0.01 e | ||
| 4 Kbc (µM) | 7.4 ± 5.2 | 3.05 ± 0.44 | ||
| zc | 0.30 ± 0.21 e | 0.0* | ||
| SSQ | 90.3005 | 106.822 | ||
| Closed-channel block scales with movement of each voltage sensor; open channels are blocked identically | ||||
| Scheme 5 | Scheme 5a′ | Scheme 5b′ | ||
| Kbo (µM) | 6.03 ± 0.28 | 6.38 ± 0.26 | ||
| zo | 0.10 ± 0.02 e | 0.12 ± 0.01 e | ||
| 4 Kbc (µM) | 8.52 ± 6.4 | 3.21 ± 0.48 | ||
| zc | 0.33 ± 0.23 e | 0.0* | ||
| SSQ | 95.99 | 121.019 | ||
| Closed channel block depends on movement of two voltage sensors | ||||
| Scheme 6 | Scheme 6a′ | Scheme 6b′ | ||
| Kbo (µM) | 6.04 ± 0.24 | 5.70 ± 0.23 | ||
| zo | 0.10 ± 0.02 e | 0.069 ± 0.01 e | ||
| 4 Kbc (µM) | 0.02 ± 0.02 | .174 ± 0.02 | ||
| zc | 0.62 ± 0.23 e | 0.0* | ||
| SSQ | 89.91 | 124.9026 | ||
| Basic open-channel block | ||||
| Scheme 1 | Scheme 1a | |||
| Kbo (µM) | 5.90 ± 0.40 | |||
| zc | 0.13 ± 0.02 e | |||
| Kbc (µM) | ||||
| zc | ||||
| SSQ | 395.95 | |||
| State-independent closed- and open-channel block and variations | ||||
| Scheme 2 | Scheme 2a | Scheme 2a′ | Scheme 2b | Scheme 2b′ |
| Kbo (µM) | 7.42 ± 0.43 | 6.01 ± 0.30 | 6.96 ± 0.39 | 6.36 ± 0.45 |
| zc | 0.17 ± 0.02 e | 0.10 ± 0.02 e | 0.15 ± 0.2 e | 0.15 ± 0.02 e |
| Kbc (µM) | =Kbo | 45.79 ± 35.9 | =Kbo | 21.4 ± 12.2 |
| zc | =zc | 0.81 ± 0.20 e | 0.0* | 0.0* |
| SSQ | 309.199 | 100.66 | 486.663 | 326.09 |
| Block dependent on movement of one voltage sensor | ||||
| Scheme 3 | Scheme 3a | Scheme 3a′ | Scheme 3b | Scheme 3b′ |
| Kbo (µM) | 6.14 ± 0.26 | 6.01 ± 0.27 | 6.02 ± 0.29 | 6.48 ± 0.29 |
| zo | 0.13 ± 0.01 e | 0.10 ± 0.02 e | 0.13 ± 0.02 e | 0.13 ± 0.01 e |
| Kbc (µM) | =Kbo | 8.1 ± 6.7 | =Kbo | 2.34 ± 0.38 |
| zc | =zc | 0.44 ± 0.23 e | 0.0 | 0.0* |
| SSQ | 159.163 | 93.75 | 209.18 | 138.242 |
| Block scales with movement of each voltage sensor | ||||
| Scheme 4 | Scheme 4a′ | Scheme 4b′ | ||
| 4 Kbo (µM) | 19.53 ± 0.9 | 20.78 ± 0.80 | ||
| zo | 0.06 ± 0.02 e | 0.08 ± 0.01 e | ||
| 4 Kbc (µM) | 7.4 ± 5.2 | 3.05 ± 0.44 | ||
| zc | 0.30 ± 0.21 e | 0.0* | ||
| SSQ | 90.3005 | 106.822 | ||
| Closed-channel block scales with movement of each voltage sensor; open channels are blocked identically | ||||
| Scheme 5 | Scheme 5a′ | Scheme 5b′ | ||
| Kbo (µM) | 6.03 ± 0.28 | 6.38 ± 0.26 | ||
| zo | 0.10 ± 0.02 e | 0.12 ± 0.01 e | ||
| 4 Kbc (µM) | 8.52 ± 6.4 | 3.21 ± 0.48 | ||
| zc | 0.33 ± 0.23 e | 0.0* | ||
| SSQ | 95.99 | 121.019 | ||
| Closed channel block depends on movement of two voltage sensors | ||||
| Scheme 6 | Scheme 6a′ | Scheme 6b′ | ||
| Kbo (µM) | 6.04 ± 0.24 | 5.70 ± 0.23 | ||
| zo | 0.10 ± 0.02 e | 0.069 ± 0.01 e | ||
| 4 Kbc (µM) | 0.02 ± 0.02 | .174 ± 0.02 | ||
| zc | 0.62 ± 0.23 e | 0.0* | ||
| SSQ | 89.91 | 124.9026 | ||