TABLE I.

Comparison of data and model values for muscarinic inhibition of the indicated Kv7 channels by oxo-M

Channel Data Model 
 EC50 Inhibmax EC50 Inhibmax 
 µM % µM % 
Kv7.2wt/7.3wt 0.44 ± 0.08 74 ± 3 0.54 81 
Kv7.3T 1.0 ± 0.76 39 ± 3 1.05 41 
Kv7.4wt 0.066 ± 0.008 81 ± 6 0.10 99 
Kv7.2 (R463E)/7.3T 0.58 ± 0.07 27 ± 3 1.05 41 
Kv7.2 (R463Q)/7.3T 0.12 ± 0.08 79 ± 6 0.13 97 
Kv7.2 (EEE)/7.3T 0.032 ± 0.004 83 ± 3 0.07 99 
Channel Data Model 
 EC50 Inhibmax EC50 Inhibmax 
 µM % µM % 
Kv7.2wt/7.3wt 0.44 ± 0.08 74 ± 3 0.54 81 
Kv7.3T 1.0 ± 0.76 39 ± 3 1.05 41 
Kv7.4wt 0.066 ± 0.008 81 ± 6 0.10 99 
Kv7.2 (R463E)/7.3T 0.58 ± 0.07 27 ± 3 1.05 41 
Kv7.2 (R463Q)/7.3T 0.12 ± 0.08 79 ± 6 0.13 97 
Kv7.2 (EEE)/7.3T 0.032 ± 0.004 83 ± 3 0.07 99 

The values for both data and model were taken from Hill equation fits in both cases.

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