Comparison of data and model values for muscarinic inhibition of the indicated Kv7 channels by oxo-M
| Channel | Data | Model | ||
| EC50 | Inhibmax | EC50 | Inhibmax | |
| µM | % | µM | % | |
| Kv7.2wt/7.3wt | 0.44 ± 0.08 | 74 ± 3 | 0.54 | 81 |
| Kv7.3T | 1.0 ± 0.76 | 39 ± 3 | 1.05 | 41 |
| Kv7.4wt | 0.066 ± 0.008 | 81 ± 6 | 0.10 | 99 |
| Kv7.2 (R463E)/7.3T | 0.58 ± 0.07 | 27 ± 3 | 1.05 | 41 |
| Kv7.2 (R463Q)/7.3T | 0.12 ± 0.08 | 79 ± 6 | 0.13 | 97 |
| Kv7.2 (EEE)/7.3T | 0.032 ± 0.004 | 83 ± 3 | 0.07 | 99 |
| Channel | Data | Model | ||
| EC50 | Inhibmax | EC50 | Inhibmax | |
| Kv7.2wt/7.3wt | 0.44 ± 0.08 | 74 ± 3 | 0.54 | 81 |
| Kv7.3T | 1.0 ± 0.76 | 39 ± 3 | 1.05 | 41 |
| Kv7.4wt | 0.066 ± 0.008 | 81 ± 6 | 0.10 | 99 |
| Kv7.2 (R463E)/7.3T | 0.58 ± 0.07 | 27 ± 3 | 1.05 | 41 |
| Kv7.2 (R463Q)/7.3T | 0.12 ± 0.08 | 79 ± 6 | 0.13 | 97 |
| Kv7.2 (EEE)/7.3T | 0.032 ± 0.004 | 83 ± 3 | 0.07 | 99 |
The values for both data and model were taken from Hill equation fits in both cases.
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