TABLE I.

Gm in EDL muscle fibers before AP firing

Experimental conditions GmS GmS,50 GKS GClS GClS,50 
 µS/cm2 µS/cm2 µS/cm2 µS/cm2 µS/cm2 
50 µM BTS 1,458 ± 70 (n = 26/7) 361 ± 21 (n = 15/4) 144 ± 16 (n = 13/6) 1,314 ± 72 217 ± 26 
50 µM BTS + 10 µM glibenclamide 1,252 ± 42 (n = 24/4) 524 ± 27 (n = 11/2) 195 ± 32 (n = 6/2) 1,057 ± 53 329 ± 42 
50 µM BTS + 100 µM 5-HD 1,609 ± 82 (n = 14/2) ND ND NA NA 
50 µM BTS + 100 µM 9-AC + 0.01 µM TTX 143 ± 13 (n = 9/2) ND ND NA NA 
Experimental conditions GmS GmS,50 GKS GClS GClS,50 
 µS/cm2 µS/cm2 µS/cm2 µS/cm2 µS/cm2 
50 µM BTS 1,458 ± 70 (n = 26/7) 361 ± 21 (n = 15/4) 144 ± 16 (n = 13/6) 1,314 ± 72 217 ± 26 
50 µM BTS + 10 µM glibenclamide 1,252 ± 42 (n = 24/4) 524 ± 27 (n = 11/2) 195 ± 32 (n = 6/2) 1,057 ± 53 329 ± 42 
50 µM BTS + 100 µM 5-HD 1,609 ± 82 (n = 14/2) ND ND NA NA 
50 µM BTS + 100 µM 9-AC + 0.01 µM TTX 143 ± 13 (n = 9/2) ND ND NA NA 

The subscript S indicates values for Gm before AP firing under the various experimental conditions as determined using the classical technique (Fig. 1 and Eq. 1). GmS,50 represents Gm before AP firing at 50 mM Cl. GKS and GClS represent component conductances of GmS for K+ and Cl, respectively, whereas GClS,50 represents the component conductance of GmS,50 for Cl. All data have been presented as means ± SEM. n represents fibers/muscles. NA, not applicable.

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