Comparison of unitary current amplitudes for wild-type and mutant channels at [K+] = 1 M (current represented in pA as means ± SEM with n = 3–9)
| −60 mV | +60 mV | |||||
| pH 5.5 | pH 7.4 | pH 8.5 | pH 5.5 | pH 7.4 | pH 8.5 | |
| Wild-type | 5.3 ± 0.2 | 9.3 ± 0.4 | 11 ± 0.3 | 13 ± 0.4 | 16 ± 0.4 | 17 ± 0.5 |
| E636Q | 6 ± 1 | 8 ± 0.6 | 8.7 ± 0.6 | 12 ± 0.5 | 13 ± 0.7 | 14 ± 0.9 |
| D646N | 5.5 ± 0.2 | 7 ± 0.2 | 7.8 ± 0.1 | 11 ± 0.5 | 12 ± 0.3 | 13 ± 0.5 |
| E636Q/D646N | 5 ± 0.1 | 5.4 ± 0.2 | 5.7 ± 0.2 | 8.2 ± 0.2 | 8.9 ± 0.2 | 9.3 ± 0.4 |
| −60 mV | +60 mV | |||||
| pH 5.5 | pH 7.4 | pH 8.5 | pH 5.5 | pH 7.4 | pH 8.5 | |
| Wild-type | 5.3 ± 0.2 | 9.3 ± 0.4 | 11 ± 0.3 | 13 ± 0.4 | 16 ± 0.4 | 17 ± 0.5 |
| E636Q | 6 ± 1 | 8 ± 0.6 | 8.7 ± 0.6 | 12 ± 0.5 | 13 ± 0.7 | 14 ± 0.9 |
| D646N | 5.5 ± 0.2 | 7 ± 0.2 | 7.8 ± 0.1 | 11 ± 0.5 | 12 ± 0.3 | 13 ± 0.5 |
| E636Q/D646N | 5 ± 0.1 | 5.4 ± 0.2 | 5.7 ± 0.2 | 8.2 ± 0.2 | 8.9 ± 0.2 | 9.3 ± 0.4 |