TABLE I. HA Model Gating Parameters (... | Rockefeller University Press

TABLE I.

HA Model Gating Parameters (Horrigan and Aldrich, 2002)

L	C-O equilibrium constant (unliganded channel, resting voltage sensors).
	L=L₀ exp(z_LV/kT)
	L₀, z_L The zero voltage value of L and its partial charge, respectively.
J	R-A equilibrium constant (closed, unliganded channel).
	J = J₀ exp(z_JV/kT)
	J₀, z_J The zero voltage value of J and its partial charge, respectively.
K	Equilibrium constant for Ca²⁺ binding (closed channel, resting voltage sensors).
	K=[Ca²⁺] / K_C
	K_C Ca²⁺ dissociation constant (closed channel, resting voltage-sensors).
C	Allosteric factor describing interaction between channel opening and Ca²⁺ binding.
	C = K_C / K_O
	K_O Ca²⁺ dissociation constant (open channel, resting voltage-sensors).
D	Allosteric factor describing interaction between channel opening and voltage sensor activation.
	D = exp [-z_J (Vh_o-Vh_c)/kT]
	Vh_O, Vh_C Half-activating voltage of Q_C and Q_O, respectively
	Q_C, Q_O Steady-state gating charge distribution for closed or open channels.
E	Allosteric factor describing interaction between Ca²⁺ binding and voltage-sensor activation.