TABLE I.

Midpoints and slope factors of the activation curves of CaV1.2 IIS6 mutants

Mutant Half-activation Slope 
 mV mV 
Wild-typea −9.9 ± 1.1 6.3 ± 0.7 
A780Pa −37.1 ± 0.7 5.7 ± 0.8 
A780G −19.3 ± 0.8 6.3 ± 0.6 
I781Pa −47.2 ± 1.1 6.3 ± 0.6 
I781G −40.2 ± 0.8 7.5 ± 0.7 
I781Ta −37.7 ± 1.2 7.2 ± 1.0 
A782Pa −35.7 ± 1.4 9.8 ± 0.3 
A782G −22.2 ± 0.4 7.8 ± 0.4 
V783G No current No current 
D784G −15.6 ± 1.1 6.3 ± 0.6 
Mutant Half-activation Slope 
 mV mV 
Wild-typea −9.9 ± 1.1 6.3 ± 0.7 
A780Pa −37.1 ± 0.7 5.7 ± 0.8 
A780G −19.3 ± 0.8 6.3 ± 0.6 
I781Pa −47.2 ± 1.1 6.3 ± 0.6 
I781G −40.2 ± 0.8 7.5 ± 0.7 
I781Ta −37.7 ± 1.2 7.2 ± 1.0 
A782Pa −35.7 ± 1.4 9.8 ± 0.3 
A782G −22.2 ± 0.4 7.8 ± 0.4 
V783G No current No current 
D784G −15.6 ± 1.1 6.3 ± 0.6 
a

Data from Hohaus et al. (2005).

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