TABLE II.

Summary of basal bath Δ[HCO3]-induced TEP responses

Inhibitor/conditiona 2.62 mM basal bath [HCO3]-induced TEP response (mV)b 
Apical Basal Control w/ inhibitor Recovery Pc n 
 DIDS 1.41 ± 0.69 0.42 ± 0.29 0.56 ± 0.25 <0.05 
Na-free Na-free 1.01 ± 0.21 0.04 ± 0.07 0.79 ± 0.38 <0.05 
amiloride  1.28 ± 0.58 1.24 ± 0.50 1.23 ± 0.40 >0.05 
bumetanide  0.89 ± 0.28 0.80 ± 0.18 0.97 ± 0.29 >0.05 
ouabain  1.26 ± 0.59 1.17 ± 0.49 1.19 ± 0.51 >0.05 
DIDS  0.86 ± 0.16 0.49 ± 0.07 0.63 ± 0.15 <0.05 
 DZA 1.44 ± 0.80 0.98 ± 0.50 1.06 ± 0.55 <0.05 
13% CO2  1.11 ± 0.67 1.35 ± 0.78 1.07 ± 0.67 <0.05 
1% CO2  1.26 ± 0.74 0.37 ± 0.32 0.99 ± 0.59 <0.05 
Inhibitor/conditiona 2.62 mM basal bath [HCO3]-induced TEP response (mV)b 
Apical Basal Control w/ inhibitor Recovery Pc n 
 DIDS 1.41 ± 0.69 0.42 ± 0.29 0.56 ± 0.25 <0.05 
Na-free Na-free 1.01 ± 0.21 0.04 ± 0.07 0.79 ± 0.38 <0.05 
amiloride  1.28 ± 0.58 1.24 ± 0.50 1.23 ± 0.40 >0.05 
bumetanide  0.89 ± 0.28 0.80 ± 0.18 0.97 ± 0.29 >0.05 
ouabain  1.26 ± 0.59 1.17 ± 0.49 1.19 ± 0.51 >0.05 
DIDS  0.86 ± 0.16 0.49 ± 0.07 0.63 ± 0.15 <0.05 
 DZA 1.44 ± 0.80 0.98 ± 0.50 1.06 ± 0.55 <0.05 
13% CO2  1.11 ± 0.67 1.35 ± 0.78 1.07 ± 0.67 <0.05 
1% CO2  1.26 ± 0.74 0.37 ± 0.32 0.99 ± 0.59 <0.05 
a

Blank cells indicate that control Ringer was perfused into the corresponding bath.

b

All values are reported as mean ± SD.

c

The basal bath Δ[HCO3]-induced TEP response in control Ringer was compared to the TEP response in the presence of the inhibitor/condition; P < 0.05 is considered significant by Student’s t test.

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