TABLE IV Common attributes of ECCE and... | Rockefeller University Press

TABLE IV

Common attributes of ECCE and the skeletal muscle L-type current

	ECCE	I_L
Is voltage-dependent	yes^{^a}^{^b}	yes^{^c}^{^d}^{^e}
Conducts Ca²⁺	yes^{^a}^{^b}^{^c}^{^f}	yes^{^c}^{^d}^{^e}
Requires α_1S subunit	yes^{^a}^{^b}^{^e}	yes^{^c}^{^d}
Requires β_1a subunit	yes^{^e}	increased expression^{^g}^{^h}^ⁱ^{^j}
Reduced by siRNA against α₂δ₁ subunit	yes^{^k}	faster inactivation^{^k}^{^l}
Requires RYR1	yes^{^a}^{^b}^{^e}^{^f}	greatly potentiated^{^m}^ⁿ
Blocked by 100 μM La³⁺	substantial^{^o}	complete^{^e}
Blocked by 100 μM Gd³⁺	complete^{^a}^{^p}^{^e}	complete^{^e}
Blocked by 20 μM SKF 96356	complete^{^a}^{^b}^{^o}	complete^{^e}
Blocked by 100 μM 2-APB	∼80%^{^a}^{^b}	∼80%^{^e}
Blocked by 1 μM nifedipine	incomplete^{^o}	incomplete^{^e}
Blocked by 50 μM nifedipine	complete^{^e}	complete^{^e}
Reduced by ≥10 μM dantrolene	partial^{^e}^{^q}	modest^{^e}^{^r}
Conducts Mn²⁺	yes^{^a}^{^b}^{^f}^{^k}^{^q}	yes^{^e}
Divalent entry via SkEIIIK	yes^{^a}	yes^{^e}
Mediated by Orai1/STIM1	no^{^f}	no^{^c}^{^d}

	ECCE	I_L
Is voltage-dependent	yes^{^a}^{^b}	yes^{^c}^{^d}^{^e}
Conducts Ca²⁺	yes^{^a}^{^b}^{^c}^{^f}	yes^{^c}^{^d}^{^e}
Requires α_1S subunit	yes^{^a}^{^b}^{^e}	yes^{^c}^{^d}
Requires β_1a subunit	yes^{^e}	increased expression^{^g}^{^h}^ⁱ^{^j}
Reduced by siRNA against α₂δ₁ subunit	yes^{^k}	faster inactivation^{^k}^{^l}
Requires RYR1	yes^{^a}^{^b}^{^e}^{^f}	greatly potentiated^{^m}^ⁿ
Blocked by 100 μM La³⁺	substantial^{^o}	complete^{^e}
Blocked by 100 μM Gd³⁺	complete^{^a}^{^p}^{^e}	complete^{^e}
Blocked by 20 μM SKF 96356	complete^{^a}^{^b}^{^o}	complete^{^e}
Blocked by 100 μM 2-APB	∼80%^{^a}^{^b}	∼80%^{^e}
Blocked by 1 μM nifedipine	incomplete^{^o}	incomplete^{^e}
Blocked by 50 μM nifedipine	complete^{^e}	complete^{^e}
Reduced by ≥10 μM dantrolene	partial^{^e}^{^q}	modest^{^e}^{^r}
Conducts Mn²⁺	yes^{^a}^{^b}^{^f}^{^k}^{^q}	yes^{^e}
Divalent entry via SkEIIIK	yes^{^a}	yes^{^e}
Mediated by Orai1/STIM1	no^{^f}	no^{^c}^{^d}

References:

Cherednichenko et al., 2004.

Hurne et al., 2005.

Beam et al., 1986.

Tanabe et al., 1988.

This paper.

Lyfenko and Dirksen, 2008.

Gregg et al., 1995.

Strube et al., 1996.

Papadopoulos et al., 2004.

Sheridan et al., 2004.

Gach et al., 2008.

Obermair et al., 2005.

Nakai et al., 1996.

Avila and Dirksen, 2000.

Yang et al., 2007.

Cherednichenko et al., 2004, no concentration reported.

Cherednichenko et al., 2008.

Szentesi et al., 2001.