Activation and Decay of L-type Current during Extended Depolarizations
. | Ipeak (pA/pF) . | tpeak (s) . | t1/2 decay (s) . | r9 (%) . |
|---|---|---|---|---|
| normal (−10 mV) | −0.7 ± 0.2 (5) | 4.02 ± 1.02 (6) | ND | 0.64 ± 0.10 (6) |
| normal (0 mV) | −2.3 ± 0.6 (5) | 2.54 ± 1.14 (6) | 2.65 ± 0.34 (6) | 0.52 ± 0.10 (6) |
. | Ipeak (pA/pF) . | tpeak (s) . | t1/2 decay (s) . | r9 (%) . |
|---|---|---|---|---|
| normal (−10 mV) | −0.7 ± 0.2 (5) | 4.02 ± 1.02 (6) | ND | 0.64 ± 0.10 (6) |
| normal (0 mV) | −2.3 ± 0.6 (5) | 2.54 ± 1.14 (6) | 2.65 ± 0.34 (6) | 0.52 ± 0.10 (6) |
Data presented here were obtained from 9.8-s test potentials from −80 to −10 and 0 mV with 2 mM Ca2+ in the external recording solution. r9 is ratio of the current remaining at 9 s to the peak current. t1/2 decay at −10 mV was not determined (ND) because the test potential was too short to accurately assess this parameter in three of six cells. Data are given as mean ± SEM, with the numbers in parentheses indicating the number of myotubes tested.