Conductance Fits
. | . | G-V . | . |
|---|---|---|---|
| Gmax (nS/nF) | V1/2 (mV) | kG (mV) | |
| normal (10 mM Ca2+ external) | 244 ± 12 (10) | 18.1 ± 1.4 | 4.4 ± 0.2 |
| normal (2 mM Ca2+ external) | 115 ± 16a (4) | 7.8 ± 2.4b | 4.7 ± 0.5 |
| normal (10 mM Ca2+ external) + 10 μM dantrolene | 228 ± 10 (12) | 22.4 ± 0.8b | 5.2 ± 0.2b |
| normal (10 mM Mn2+ external) | 135 ± 6b (4) | 16.7 ± 1.9 | 5.6 ± 0.2b |
. | . | G-V . | . |
|---|---|---|---|
| Gmax (nS/nF) | V1/2 (mV) | kG (mV) | |
| normal (10 mM Ca2+ external) | 244 ± 12 (10) | 18.1 ± 1.4 | 4.4 ± 0.2 |
| normal (2 mM Ca2+ external) | 115 ± 16a (4) | 7.8 ± 2.4b | 4.7 ± 0.5 |
| normal (10 mM Ca2+ external) + 10 μM dantrolene | 228 ± 10 (12) | 22.4 ± 0.8b | 5.2 ± 0.2b |
| normal (10 mM Mn2+ external) | 135 ± 6b (4) | 16.7 ± 1.9 | 5.6 ± 0.2b |
Data are given as mean ± SEM, with the numbers in parentheses indicating the number of myotubes tested. Data were fit according to Eq. 1 (see Materials and Methods). Asterisks indicate significant differences compared to L-type currents recorded from normal, untreated myotubes in 10 mM external Ca2+
P < 10−4, t test.
P < 0.01, t test.