TABLE I

Deactivation Values at −100 mV

Channel
τfast (ms)
τslow (ms)
τaverage (ms)
n
Ctrl 64.3 ± 3.1 254.7 ± 10.3 123.9 ± 6.1 
S654C 84.4 ± 5.2a 486.5 ± 38.9b 285.5 ± 41.4b 
I655C 139.4 ± 4.9b 734.5 ± 22.8b 504.8 ± 21.8b 10 
F656C 71.8 ± 14.1 259.4 ± 60.1 107.2 ± 7.1 
G657C 14.8 ± 1.3b 104.5 ± 12.9b 40.5 ± 4.3b 
N658C 5.5 ± 0.03b 51.1 ± 2.9a 11.7 ± 1.5b 
V659C 113.6 ± 6.4b 1,084.9 ± 40.7b 798.6 ± 62.9b 
S660C 49.3 ± 3.6a 142.7 ± 8.7b 107.9 ± 2.5b 
A661C 91.1 ± 6.5a 321.9 ± 24.7b 188.1 ± 15.3b 
I662C 92.9 ± 2.7a 506.2 ± 75.1b 400.4 ± 70.2b 
I663C 112.3 ± 5.4b 394.9 ± 15.5b 258.9 ± 13.7b 
Q664C 106.6 ± 8.2b 1,044.4 ± 67.2b 764.9 ± 69.2b 
R665C 81.8 ± 16.8 319.7 ± 71.8b 147.3 ± 16.8 
L666C 71.8 ± 13.1 147.2 ± 4.7b 99.4 ± 8.0a 
Y667C 138.7 ± 7.7b 802.9 ± 56.5b 627.03 ± 67.6b 
S668C 197.9 ± 25.5b 1,809.7 ± 118.2b 1,489.3 ± 85.6a 13 

Values reported were obtained by double exponential fits to deactivating current traces (see Materials and methods). Values are ± SEM.

a

P < 0.05.

b

P < 0.001.

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