TABLE V Parameters of the... | Rockefeller University Press

TABLE V

Parameters of the Luminal-triggered Ca2+ Feedthrough Model

	Affinity	Opening rates	Closing rates	Feedthrough
L-site	K_CaL = 40 μM
L-site		K_MgL = 40 μM	α = 1 s⁻¹^{^a}
		β = 7 s⁻¹^{^a}	δ = 1,500 s⁻¹
A-site	K_CaA = 1.2 μM	γ = 60 s⁻¹	ε = 1.5 s⁻¹	X_Ca = 12 μM/pA
A-site		K_MgA = 60 μM			X_Mg = 120 μM/pA
I₂-site	K_CaI = 1.2 μM	φ = 800 s⁻¹	θ = 1,000 s⁻¹	Y_Ca = 0.35 μM/pA
I₂-site		φ = 800 s⁻¹	K_MgI unknown	Y_Ca = 0.35 μM/pA		λ = 0 s⁻¹
I₁-site			η = 1.5 ×10⁵ (Ms)⁻¹

	Affinity	Opening rates	Closing rates	Feedthrough
L-site	K_CaL = 40 μM
L-site		K_MgL = 40 μM	α = 1 s⁻¹^{^a}
		β = 7 s⁻¹^{^a}	δ = 1,500 s⁻¹
A-site	K_CaA = 1.2 μM	γ = 60 s⁻¹	ε = 1.5 s⁻¹	X_Ca = 12 μM/pA
A-site		K_MgA = 60 μM			X_Mg = 120 μM/pA
I₂-site	K_CaI = 1.2 μM	φ = 800 s⁻¹	θ = 1,000 s⁻¹	Y_Ca = 0.35 μM/pA
I₂-site		φ = 800 s⁻¹	K_MgI unknown	Y_Ca = 0.35 μM/pA		λ = 0 s⁻¹
I₁-site			η = 1.5 ×10⁵ (Ms)⁻¹

The parameters are described in the text (see Eqs. 2–13 and schemes 1–5 in Fig. 10). The voltage-dependencies are given by the multiplying factor

\[\mathrm{exp}(0.4{\,}F\mathrm{{\Delta}}V/RT),\]

where ΔV is the difference in the voltage from −40 mV.

Parameters that depend on voltage where the values given are those measured at −40 mV.