Summary of Kinetic Parameters for QA Block of TRPV1a
| Blocker . | Association rate constant kon(0 mV), (M−1s−1) . | Dissociation rate constant koff (0 mV), (s−1) . | zon (eo) . | zoff (eo) . |
|---|---|---|---|---|
| TEA (n = 3) | 1.04 × 106 ± 4.8 × 105 | 2.89 × 104 ± 3.2 × 103 | 0.94 ± 0.13 | 0.27 ± 0.03 |
| TPrA (n = 3) | 8.59 × 105 ± 1.5 × 105 | 1.23 × 104 ± 186 | 0.69 ± 0.14 | −0.19 ± 0.01 |
| TBA (n = 6) | 2.5 × 105 ± 2.9 × 104 | 83.76 ± 10 | 0.93 ± 0.03 | −0.63 ± 0.03 |
| TPA (n = 5) | 1.03 × 105 ± 4 × 104 | 10.73 ± 0.95 | 0.68 ± 0.06 | −0.45 ± 0.02 |
| Blocker . | Association rate constant kon(0 mV), (M−1s−1) . | Dissociation rate constant koff (0 mV), (s−1) . | zon (eo) . | zoff (eo) . |
|---|---|---|---|---|
| TEA (n = 3) | 1.04 × 106 ± 4.8 × 105 | 2.89 × 104 ± 3.2 × 103 | 0.94 ± 0.13 | 0.27 ± 0.03 |
| TPrA (n = 3) | 8.59 × 105 ± 1.5 × 105 | 1.23 × 104 ± 186 | 0.69 ± 0.14 | −0.19 ± 0.01 |
| TBA (n = 6) | 2.5 × 105 ± 2.9 × 104 | 83.76 ± 10 | 0.93 ± 0.03 | −0.63 ± 0.03 |
| TPA (n = 5) | 1.03 × 105 ± 4 × 104 | 10.73 ± 0.95 | 0.68 ± 0.06 | −0.45 ± 0.02 |
The table summarizes the on- and off-rates for the four blockers used in this study and their associated valence.
Data are mean ± SEM.