TABLE I Summary of V 1/2 Changes... | Rockefeller University Press

TABLE I

Summary of V_1/2 Changes Associated with Zn²⁺ Application to Kv1.2 Mutations

	n	Control V_1/2	1 μM Zn²⁺ V_1/2	ΔV_1/2
		mV	mV	mV
R294H	9	−4.7 ± 0.5	−13.6 ± 0.6	−8.9
A351H	8	−7.9 ± 0.5	−11.3 ± 0.5	−3.4
D352H	7	−0.9 ± 0.6	−0.3 ± 0.6	+0.6
R294H-D352H	7	−10.8 ± 0.4	−25.7 ± 0.6	−14.9
D352G-E353S	7	−17.3 ± 0.5	−15.9 ± 0.6	+1.4
R294H-D352G-E353S	7	−1.7 ± 0.5	−1.6 ± 0.5	+0.1
A351H-D352G-E353S	7	−12.8 ± 0.5	−16.5 ± 0.5	−3.7
R294H-A351H-D352G-E353S	9	−2.2 ± 0.8	−29.6 ± 0.6	−27.4

	n	Control V_1/2	1 μM Zn²⁺ V_1/2	ΔV_1/2
		mV	mV	mV
R294H	9	−4.7 ± 0.5	−13.6 ± 0.6	−8.9
A351H	8	−7.9 ± 0.5	−11.3 ± 0.5	−3.4
D352H	7	−0.9 ± 0.6	−0.3 ± 0.6	+0.6
R294H-D352H	7	−10.8 ± 0.4	−25.7 ± 0.6	−14.9
D352G-E353S	7	−17.3 ± 0.5	−15.9 ± 0.6	+1.4
R294H-D352G-E353S	7	−1.7 ± 0.5	−1.6 ± 0.5	+0.1
A351H-D352G-E353S	7	−12.8 ± 0.5	−16.5 ± 0.5	−3.7
R294H-A351H-D352G-E353S	9	−2.2 ± 0.8	−29.6 ± 0.6	−27.4