The model has been modified from Bähring et al. (2001). The voltage-dependent rates are of the form α = α₀·exp[z_aV/(RT/F)] for the forward rates and β = β₀·exp[z_bV/(RT/F)] for the backward rates, where α₀ and β₀ are the rates at 0 mV and z_a and z_b are the equivalent charges moving up to the transition state. Channel opening and closing are defined by k_co and k_oc, respectively, open-state inactivation by k_oi and k_io, and closed-state inactivation by k_ci and k_ic. A deep-inactivated state, defined by k_ics and k_csi, has been introduced to reproduce the biexponential recovery from inactivation. All closed states are connected to inactivated states via k_ci and k_ic. The coupling of activation and inactivation is defined by an allosteric factor f. Transition leading from I_O to I_S is defined by k_is and k_si. Column G0 represents the gating model for Kv4.3 homotetramers, G1 for Kv4.3/DPPX heteromultimers, and G2 the gating of these heteromultimers at saturating TEA concentrations of the high affinity binding site. Total conductance as a function of TEA concentration and the relative contribution of homo and heteromultimers are computed with the following expression:where Kd1, Kd2, and Kd3 are the affinity dissociation constants obtained experimentally, and r represent the percentage of Kv4.3/DPPX present in the membrane.