Gating Parameters of Kv4.2 Channels
. | Kv4.2 WT . | Kv4.2 CTX-sensitive mutant . | Δ2–40 Kv4.2 CTX-sensitive mutant . |
|---|---|---|---|
| Gp-V: V1/2 (mV) | −6.6 ± 1.5 (4)a | −13.4 ± 2.9b (7) | −22.1 ± 2.0b (4) |
| k (mV) | 26.7 ± 1.1 (4)a | 22.4 ± 1.1 (7) | 23.1 ± 1.5 (4) |
| ISS: V1/2 (mV) | −77.4 ± 1.4b (5) | −80.1 ± 2.2 (5) | −84.0 ± 1.0b (4) |
| k (mV) | 4.0 ± 0.2 (5) | 4.5 ± 0.2 (5) | 4.6 ± 0.3 (4) |
| QONV: V1/2 (mV) | −40.4 ± 2.2 (6) | −37.3 ± 2.2 (8) | |
| z (e0) | 3.1 ± 0.3 (6) | 3.6 ± 0.2 (8) | |
| Q availability: V1/2 (mV) | −50.1 ± 2.5 (3)c | −55.6 ± 3.4 (3)c | |
| z (e0) | 2.2 ± 0.2 (3) | 1.7 ± 0.2 (3) |
. | Kv4.2 WT . | Kv4.2 CTX-sensitive mutant . | Δ2–40 Kv4.2 CTX-sensitive mutant . |
|---|---|---|---|
| Gp-V: V1/2 (mV) | −6.6 ± 1.5 (4)a | −13.4 ± 2.9b (7) | −22.1 ± 2.0b (4) |
| k (mV) | 26.7 ± 1.1 (4)a | 22.4 ± 1.1 (7) | 23.1 ± 1.5 (4) |
| ISS: V1/2 (mV) | −77.4 ± 1.4b (5) | −80.1 ± 2.2 (5) | −84.0 ± 1.0b (4) |
| k (mV) | 4.0 ± 0.2 (5) | 4.5 ± 0.2 (5) | 4.6 ± 0.3 (4) |
| QONV: V1/2 (mV) | −40.4 ± 2.2 (6) | −37.3 ± 2.2 (8) | |
| z (e0) | 3.1 ± 0.3 (6) | 3.6 ± 0.2 (8) | |
| Q availability: V1/2 (mV) | −50.1 ± 2.5 (3)c | −55.6 ± 3.4 (3)c | |
| z (e0) | 2.2 ± 0.2 (3) | 1.7 ± 0.2 (3) |
The number of independent experiments is indicated in parentheses.
Data taken from Table I of Dougherty and Covarrubias, 2006.
Differences between the mean values are statistically significant at the P < 0.05 level in a one-way ANOVA test. Differences between the means of all other parameters are not statistically significant at P < 0.05
From experiments shown in Fig. 9 C.