Average Parameters of Various Homomeric or Heteromeric Channels Obtained from Global Fitting
| S1-WT+S1-ND . | . | . | . | . | . |
|---|---|---|---|---|---|
| Component | 0 | 1 | 2 | 3 | 4 |
| K0 (μM) | 2.48 ± 0.17 (14) | 6.97 ± 0.49 (14) | 288 ± 9.9 (14) | 2220 ± 313 (14) | 3610 ± 458 (15) |
| ρ | 3.08 ± 0.07 (14) | 2.89 ± 0.07 (14) | 2.63 ± 0.03 (14) | 0.83 ± 0.03 (14) | 0.66 ± 0.02 (15) |
| nH | 1.13 ± 0.01 (14) | 0.97 ± 0.03 (14) | 0.82 ± 0.02 (14) | 0.81 ± 0.02 (14) | 0.77 ± 0.03 (15) |
| Mleak | – | – | – | – | 0.72 ± 0.04 (15) |
| Kleak (μM) | – | – | – | – | 99.1 ± 11 (15) |
| S1-WT+S2-ND | |||||
| Component | 0 | 1 | 2 | 3 | 4 |
| K0 (μM) | 6.55 ± 0.34 (14) | 219 ± 3.6 (14) | 2570 ± 391 (14) | 3230 ± 185 (14) | 3610 ± 458 (15) |
| ρ | 2.84 ± 0.05 (14) | 2.74 ± 0.05 (14) | 1.49 ± 0.13 (14) | 0.75 ± 0.03 (14) | 0.66 ± 0.02 (15) |
| nH | 1.25 ± 0.01 (14) | 0.93 ± 0.05 (14) | 0.92 ± 0.04 (14) | 0.91 ± 0.04 (14) | 0.77 ± 0.03 (15) |
| Mleak | – | – | – | – | 0.72 ± 0.04 (15) |
| Kleak (μM) | – | – | – | – | 99.1 ± 11 (15) |
| S1-WT+S1-ND . | . | . | . | . | . |
|---|---|---|---|---|---|
| Component | 0 | 1 | 2 | 3 | 4 |
| K0 (μM) | 2.48 ± 0.17 (14) | 6.97 ± 0.49 (14) | 288 ± 9.9 (14) | 2220 ± 313 (14) | 3610 ± 458 (15) |
| ρ | 3.08 ± 0.07 (14) | 2.89 ± 0.07 (14) | 2.63 ± 0.03 (14) | 0.83 ± 0.03 (14) | 0.66 ± 0.02 (15) |
| nH | 1.13 ± 0.01 (14) | 0.97 ± 0.03 (14) | 0.82 ± 0.02 (14) | 0.81 ± 0.02 (14) | 0.77 ± 0.03 (15) |
| Mleak | – | – | – | – | 0.72 ± 0.04 (15) |
| Kleak (μM) | – | – | – | – | 99.1 ± 11 (15) |
| S1-WT+S2-ND | |||||
| Component | 0 | 1 | 2 | 3 | 4 |
| K0 (μM) | 6.55 ± 0.34 (14) | 219 ± 3.6 (14) | 2570 ± 391 (14) | 3230 ± 185 (14) | 3610 ± 458 (15) |
| ρ | 2.84 ± 0.05 (14) | 2.74 ± 0.05 (14) | 1.49 ± 0.13 (14) | 0.75 ± 0.03 (14) | 0.66 ± 0.02 (15) |
| nH | 1.25 ± 0.01 (14) | 0.93 ± 0.05 (14) | 0.92 ± 0.04 (14) | 0.91 ± 0.04 (14) | 0.77 ± 0.03 (15) |
| Mleak | – | – | – | – | 0.72 ± 0.04 (15) |
| Kleak (μM) | – | – | – | – | 99.1 ± 11 (15) |
Components 0–4 for S1-WT+S1-ND and S1-WT+S2-ND are defined in the text. The parameters listed for component 4 were obtained by fitting data from homomeric S1-WT channels. The parameters listed for components 0 for S1-WT+S1-ND and S1-WT+S2-ND were obtained by fitting data from homomeric S1-ND and S2-ND channels, respectively.