Table I. The first HSCs in the human... | Rockefeller University Press

Table I.

The first HSCs in the human embryo emerge in the AGM region

Carnegie stage (days)	Embryonic tissues transplanted
	AGM region	Yolk sac	Liver	Umbilical cord	Placentas
12 (26)	0/2	0/2	0/2	NA	1^c/2
13 (28)	0/2	NA	0/1	NA	1^c/2
14 (32)	1^a/7	0/7	0/7	0/4	2^c/7
15 (33)	4^a/5	0/3	0/5	0/4	1^c/2
16 (37)	2^a + 1^b/6	1^a/4	0/6	0/6	1^c/3
17 (41)	3^a/5	2^a/4	2^b/5	0/3	1^c/3
Total	10^a + 1^b/27	3^a/20	2^b/26	0/17	7^c/19

Carnegie stage (days)	Embryonic tissues transplanted
	AGM region	Yolk sac	Liver	Umbilical cord	Placentas
12 (26)	0/2	0/2	0/2	NA	1^c/2
13 (28)	0/2	NA	0/1	NA	1^c/2
14 (32)	1^a/7	0/7	0/7	0/4	2^c/7
15 (33)	4^a/5	0/3	0/5	0/4	1^c/2
16 (37)	2^a + 1^b/6	1^a/4	0/6	0/6	1^c/3
17 (41)	3^a/5	2^a/4	2^b/5	0/3	1^c/3
Total	10^a + 1^b/27	3^a/20	2^b/26	0/17	7^c/19

Cell suspensions prepared from AGM regions, yolk sacs, livers, umbilical cords, and placenta obtained from CS 12–17 human embryos were individually transplanted into irradiated NSG mice. Data shown are the number of tissues that gave human hematopoietic repopulation compared to the total number of tissues transplanted. The numbers in parentheses indicate an approximate postovulatory gestational age in days accepted for each CS (O’Rahilly and Müller, 1987). NA, not assessed.

Long-term embryonic multilineage repopulation.

Long-term embryonic unilineage T cell repopulation.

Transient maternal unilineage T cell repopulation.

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