Brief administration of R-Spo1 had no effects on immunophenotype
| Immunophenotype | +Control | +R-Spo1 |
| Spleen | ||
| CD4+ | 20.7 ± 4.2 | 17.4 ± 2.0 |
| CD8+ | 14.3 ± 2.5 | 11.9 ± 0.9 |
| CD4+Foxp3+ | 2.46 ± 0.63 | 2.46 ± 0.34 |
| B220+ | 58.5 ± 10.9 | 57.8 ± 2.9 |
| Mesenteric lymph node | ||
| CD4+ | 4.3 ± 0.7 | 4.9 ± 0.2 |
| CD8+ | 3.5 ± 0.7 | 4.2 ± 0.4 |
| CD4+Foxp3+ | 0.65 ± 0.14 | 0.70 ± 0.09 |
| Thymus | ||
| CD4+CD8+ | 96.2 ± 16.9 | 91.6 ± 19.8 |
| CD4+ | 8.4 ± 1.0 | 8.6 ± 2.1 |
| CD8+ | 3.4 ± 0.3 | 3.6 ± 0.6 |
| Immunophenotype | +Control | +R-Spo1 |
| Spleen | ||
| CD4+ | 20.7 ± 4.2 | 17.4 ± 2.0 |
| CD8+ | 14.3 ± 2.5 | 11.9 ± 0.9 |
| CD4+Foxp3+ | 2.46 ± 0.63 | 2.46 ± 0.34 |
| B220+ | 58.5 ± 10.9 | 57.8 ± 2.9 |
| Mesenteric lymph node | ||
| CD4+ | 4.3 ± 0.7 | 4.9 ± 0.2 |
| CD8+ | 3.5 ± 0.7 | 4.2 ± 0.4 |
| CD4+Foxp3+ | 0.65 ± 0.14 | 0.70 ± 0.09 |
| Thymus | ||
| CD4+CD8+ | 96.2 ± 16.9 | 91.6 ± 19.8 |
| CD4+ | 8.4 ± 1.0 | 8.6 ± 2.1 |
| CD8+ | 3.4 ± 0.3 | 3.6 ± 0.6 |
B6 mice were intravenously injected with R-Spo1 (200 µg/day) or control for 3 d, and the spleen, mesenteric lymph nodes, and thymus were harvested 6 h later. Cell numbers are shown as mean ± SD (×106). Data are representative of two independent experiments (n = 4 for +control and +R-Spo1).