Phenotype of graft-infiltrating leukocytes in T-bet−/− recipients with and without IL-17 neutralization
| Infiltrating cells . | T-bet−/− control Ig (day 14) . | T-bet−/− IL-17 neutralization (day 14) . | T-bet−/− IL-17 neutralization (day 40) . |
|---|---|---|---|
| Lymphocytes | 15.4 ± 2.1 | 3.2 ± 1.3 | 10.3 ± 3 |
| Macrophages | 21.6 ± 4.3 | 4.7 ± 1.8 | 13.6 ± 3 |
| Neutrophils | 18.4 ± 5.6 | 1.2 ± 0.3 | 4.6 ± 1.9 |
| Eosinophils | 96.1 ± 13.5 | 26.4 ± 6.5 | 71.7 ± 7.9 |
| Total | 151.1 ± 18.3 | 34.1 ± 6.9 | 100.3 ± 13.7 |
| Infiltrating cells . | T-bet−/− control Ig (day 14) . | T-bet−/− IL-17 neutralization (day 14) . | T-bet−/− IL-17 neutralization (day 40) . |
|---|---|---|---|
| Lymphocytes | 15.4 ± 2.1 | 3.2 ± 1.3 | 10.3 ± 3 |
| Macrophages | 21.6 ± 4.3 | 4.7 ± 1.8 | 13.6 ± 3 |
| Neutrophils | 18.4 ± 5.6 | 1.2 ± 0.3 | 4.6 ± 1.9 |
| Eosinophils | 96.1 ± 13.5 | 26.4 ± 6.5 | 71.7 ± 7.9 |
| Total | 151.1 ± 18.3 | 34.1 ± 6.9 | 100.3 ± 13.7 |
Five high-power fields were counted per slide, with one slide each from three to four heart grafts per group. Results are presented as mean numbers of cells ± SD.