Table III. Subsets of Rag −/− and WT DCs...

Table III.

Subsets of Rag^−/− and WT DCs in the thymus of adoptive recipients^a

WT recipients of Rag^−/− and/or WT bone marrow			pDCs	cDCs
Origin of cells	Number of thymocytes	Number of DCs	Sirpα⁺ CD11b⁻ B220⁺	Sirpα⁺ CD11b⁺ CD8α^−/lo	Sirpα⁻ CD11b⁻ CD8α^hi
	x10⁻⁶	x10⁻³	%	%	%
WT	134.5 ± 23.1^b	99.7 ± 17.6^b	21.6 ± 6.2^b	14.8 ± 3.2	63.7 ± 4.3^b^c
Rag^−/−	2.2 ± 0.5^d	15.3 ± 4.8^d	66.3 ± 0.8^d	22 ± 1.6	11.6 ± 1^d
WT	116.2 ± 24^b	69.6 ± 10.9^b	13.1 ± 0.8^b^c	13 ± 1.2^b^c	71.9 ± 4.9^b^c
plus	plus	plus
Rag^−/−	1.6 ± 0.2	28.5 ± 3.2	60.0 ± 6.1^d	28.4 ± 4.7	11.5 ± 1.6^d
WT control	149.2 ± 28.1	97.8 ± 16.4	36.5 ± 0.6	24.1 ± 3.4	38 ± 5.2

WT recipients of Rag^−/− and/or WT bone marrow			pDCs	cDCs
Origin of cells	Number of thymocytes	Number of DCs	Sirpα⁺ CD11b⁻ B220⁺	Sirpα⁺ CD11b⁺ CD8α^−/lo	Sirpα⁻ CD11b⁻ CD8α^hi
	x10⁻⁶	x10⁻³	%	%	%
WT	134.5 ± 23.1b	99.7 ± 17.6b	21.6 ± 6.2b	14.8 ± 3.2	63.7 ± 4.3bc
Rag^−/−	2.2 ± 0.5d	15.3 ± 4.8d	66.3 ± 0.8d	22 ± 1.6	11.6 ± 1d
WT	116.2 ± 24b	69.6 ± 10.9b	13.1 ± 0.8bc	13 ± 1.2bc	71.9 ± 4.9bc
plus	plus	plus
Rag^−/−	1.6 ± 0.2	28.5 ± 3.2	60.0 ± 6.1d	28.4 ± 4.7	11.5 ± 1.6d
WT control	149.2 ± 28.1	97.8 ± 16.4	36.5 ± 0.6	24.1 ± 3.4	38 ± 5.2

Data were analyzed 4 wk after adoptive transfer of Rag^−/− and/or WT bone marrow cells into 6-Gy–irradiated WT recipients.

P < 0.01 between WT and Rag^−/− cells.

P < 0.01 between WT and WT control cells.

P < 0.01 between Rag^−/− and WT control cells.

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