Impact of the Artemis-P70 mutation on lymphocyte development
| Genotype | Thymocytes | CD4+CD8+ thymocytes | Splenocytes | CD4+ LN T cells | CD8+ LN T cells | IgM+ splenocytes | Pro–B cells | Pro–B cells | Pre–B cells | Pre–B cells |
| ×106 | % | ×106 | ×106 | ×106 | % | % | ×105 | % | ×105 | |
| Art+/+ (n = 7) | 167 ± 102 | 75 ± 5 | 70.1 ± 27.95 | 3.57 ± 2.06 | 1.72 ± 0.91 | 19.84 ± 3.82 | 2.38 ± 0.65 | 0.71 ± 0.18 | 15.97 ± 5.69 | 4.63 ± 1.62 |
| Art+/P70 (n = 7) | 220 ± 106 | 78 ± 4 | 94.3 ± 43.2 | 4.61 ± 2.1 | 2.1 ± 0.6 | 18.11 ± 6.2 | 2.37 ± 0.31 | 0.897 ± 0.44 | 10.36 ± 3.25 | 4.34 ± 4.04 |
| ArtP70/P70 (n = 6) | 19 ± 10 | 22 ± 15 | 31.4 ± 19.5 | 0.43 ± 0.25 | 0.59 ± 0.2 | 3.74 ± 1.9 | 4.44 ± 1.79 | 1.34 ± 0.56 | 1.96 ± 0.56 | 0.75 ± 0.33 |
| Art−/− (n = 6) | 3 ± 2 | 7 ± 10 | 15.06 ± 11.4 | 0.059 ± 0.04 | 0.02 ± 0.013 | 0.25 ± 0.21 | 1.5 ± 1.5 | 0.55 ± 0.74 | 0.292 ± 0.23 | 0.1 ± 0.1 |
| Genotype | Thymocytes | CD4+CD8+ thymocytes | Splenocytes | CD4+ LN T cells | CD8+ LN T cells | IgM+ splenocytes | Pro–B cells | Pro–B cells | Pre–B cells | Pre–B cells |
| ×106 | % | ×106 | ×106 | ×106 | % | % | ×105 | % | ×105 | |
| Art+/+ (n = 7) | 167 ± 102 | 75 ± 5 | 70.1 ± 27.95 | 3.57 ± 2.06 | 1.72 ± 0.91 | 19.84 ± 3.82 | 2.38 ± 0.65 | 0.71 ± 0.18 | 15.97 ± 5.69 | 4.63 ± 1.62 |
| Art+/P70 (n = 7) | 220 ± 106 | 78 ± 4 | 94.3 ± 43.2 | 4.61 ± 2.1 | 2.1 ± 0.6 | 18.11 ± 6.2 | 2.37 ± 0.31 | 0.897 ± 0.44 | 10.36 ± 3.25 | 4.34 ± 4.04 |
| ArtP70/P70 (n = 6) | 19 ± 10 | 22 ± 15 | 31.4 ± 19.5 | 0.43 ± 0.25 | 0.59 ± 0.2 | 3.74 ± 1.9 | 4.44 ± 1.79 | 1.34 ± 0.56 | 1.96 ± 0.56 | 0.75 ± 0.33 |
| Art−/− (n = 6) | 3 ± 2 | 7 ± 10 | 15.06 ± 11.4 | 0.059 ± 0.04 | 0.02 ± 0.013 | 0.25 ± 0.21 | 1.5 ± 1.5 | 0.55 ± 0.74 | 0.292 ± 0.23 | 0.1 ± 0.1 |