Summary of EC50 of FR235222 on Apicomplexa and HFF primary host cells
| Cells | FR235222 EC50 (nM ± SD) | Apicidin EC50 (nM ± SD) | Pyrimethamine EC50 (nM ± SD) |
| T. gondii RH WT | 7.6 ± 0.6 | 15 ± 2 | 285 ± 61 |
| T. gondii RH M190D4 | 62 ± 5 | 67 ± 16 | 300 ± 11 |
| T. gondii Prugniaud | 10 ± 1 | – | 195 ± 1 |
| P. falciparum | 8 ± 4 | – | – |
| N. caninum | 8 ± 2 | – | – |
| HFFs | 107 ± 18 | 165 ± 33 | – |
| Cells | FR235222 EC50 (nM ± SD) | Apicidin EC50 (nM ± SD) | Pyrimethamine EC50 (nM ± SD) |
| T. gondii RH WT | 7.6 ± 0.6 | 15 ± 2 | 285 ± 61 |
| T. gondii RH M190D4 | 62 ± 5 | 67 ± 16 | 300 ± 11 |
| T. gondii Prugniaud | 10 ± 1 | – | 195 ± 1 |
| P. falciparum | 8 ± 4 | – | – |
| N. caninum | 8 ± 2 | – | – |
| HFFs | 107 ± 18 | 165 ± 33 | – |
Apicidin (HDACi) and pyrimethamine (non-HDACi) were used as controls.