Table I. CYLD and Snail1... | Rockefeller University Press

Table I.

CYLD and Snail1 immunoreactivity in relation to clinico-pathological characteristics

		CYLD IHC					Snail1 IHC
Variable	Categorization	n analyz.	neg.	weak pos. (score 1+)	strong pos. (score 2+)	P^a	n analyz.	neg.	pos.	P^a
Primary malignant melanomas^b
Age at diagnosis	>60 yr	48	25	16	7	0.647	43	16	26	1
	<60 yr	40	23	14	3		36	13	23
Gender	female	39	20	15	4	0.745	34	16	18	0.157
	male	49	28	15	6		44	13	31
Clark level	II-III	20	8	6	6	0.018	16	9	7	0.145
	IV-V	67	39	24	4		61	20	41
Tumor thickness	<1.75 mm	22	11	5	6	0.027	17	10	7	0.049
	>1.75 mm	66	37	25	4		61	19	42
Growth pattern	NOS	11	5	4	2	0.854	8	3	5	0.505
	SSM	38	20	12	6		36	14	22
	ALM	6	5	1	0		5	0	5
	NMM	30	16	12	2		27	11	16
	LMM	3	2	1	0		2	1	1

		CYLD IHC					Snail1 IHC
Variable	Categorization	n analyz.	neg.	weak pos. (score 1+)	strong pos. (score 2+)	Pa	n analyz.	neg.	pos.	Pa
Primary malignant melanomasb
Age at diagnosis	>60 yr	48	25	16	7	0.647	43	16	26	1
	<60 yr	40	23	14	3		36	13	23
Gender	female	39	20	15	4	0.745	34	16	18	0.157
	male	49	28	15	6		44	13	31
Clark level	II-III	20	8	6	6	0.018	16	9	7	0.145
	IV-V	67	39	24	4		61	20	41
Tumor thickness	<1.75 mm	22	11	5	6	0.027	17	10	7	0.049
	>1.75 mm	66	37	25	4		61	19	42
Growth pattern	NOS	11	5	4	2	0.854	8	3	5	0.505
	SSM	38	20	12	6		36	14	22
	ALM	6	5	1	0		5	0	5
	NMM	30	16	12	2		27	11	16
	LMM	3	2	1	0		2	1	1

CYLD and Snail1 immunohistochemical staining of primary malignant melanoma tissue was performed using a tissue microarray consisting of 88 cases. Investigation of CYLD protein expression was informative in all specimens, and immunohistochemical analysis of Snail1 was informative in 78 samples. NOS, not otherwise specified; SSM, superficial spreading melanoma; ALM, acral lentiginous melanoma; NMM, nodular malignant melanoma; LMM, lentigo malignant melanoma.

Fisher's exact test (two-sided). Significant data are shown is bold.

Only initial and unifocal malignant melanomas were included.

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